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MULTIPLE STRUCTURE COMPARISON USING DISTANCE DERIVED METRICS: HIV PROTEASE

MULTIPLE STRUCTURE COMPARISON USING DISTANCE DERIVED METRICS: HIV PROTEASE
使用距离导出指标进行多种结构比较：HIV 蛋白酶
批准号：
6119256
负责人：
DAVID SULLIVAN
金额：
$0.54万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
项目状态：
已结题
起止时间：
1999-07-01 至 2000-06-30
来源：
https://reporter.nih.gov/project-details/6119256
关键词：
AIDS biomedical resource computers enzymes immunology infection inflammation lymphatic system virus

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英文摘要
We are developing tools for protein structure comparison based on interatomic distances. Defining the best frame of reference for describing change is the heart of the problem. Interatomic distances have the quality of being orientation independent which facilitates analysis of an ensemble of structures. Our first data set is composed of ligated HIV protease structures. We aim to understand rules which govern structural fluctuations observed among the set. The resources of the Computer Graphics Laboratory are utilized to view different models of the HIV protease for comparison.
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