MOLECULAR CHAPERONES, SERPINS, & ION CHANNEL PROTEINS

分子伴侣、丝氨酸蛋白酶蛋白、

• 批准号: 6119399
• 负责人: PAUL CURMI
• 金额: --
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-03-01 至 2000-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6119399
• 关键词: biomaterials; proteins

GroEL is a chaperonin from E. coli. It is essential for folding proteins in vivo. An initial crystal structure of GroEL has been determined by Sigler and co-workers in the absence of nucleotides. There are several ambiguities in this structure. We have grown several crystal forms of GroEL both in the presence and absence of nucleotides. We aim to resolve the ambiguities in the native structure and determine the structural changes produced by nucleotide binding.

GroEL是大肠杆菌中的伴侣蛋白。它是折叠必不可少的