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Development and medical applications of novel tissue-adhesive biomaterials that can release proteins in a sustained manner

Development and medical applications of novel tissue-adhesive biomaterials that can release proteins in a sustained manner
能够持续释放蛋白质的新型组织粘附生物材料的开发和医学应用
批准号:
22700490
负责人:
MURAKAMI Yoshihiko
金额:
$2.41万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011

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中文摘要
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英文摘要
A novel tissue-adhesive hydrogel was prepared by using a "trilayered" polymeric micelle consisting of an aldehyde-terminated poly(ethylene glycol)-poly(D, L-lactide)(PEG-PLA) block polymer. A Schiff base is chemically formed between the amino groups in a polyallylamine and the aldehyde groups on the surface of polymeric micelles. The hydrogel was rapidly formed when the polymeric micelle solution and polyamine solution were mixed in vitro. The hydrogel was rapidly formed in vivo, and it adhered to a tissue surface.
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DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [H.Uchida, N.Nishiyama, et al, 村上義彦]
通讯作者: 村上義彦
DOI: 10.1016/j.colsurfa.2010.03.019
发表时间: 2010-05
期刊: Colloids and Surfaces A: Physicochemical and Engineering Aspects
影响因子: --
作者: [F. Ito;Y. Uchida;Y. Murakami]
通讯作者: F. Ito;Y. Uchida;Y. Murakami
Trilayered polymeric micelle : a newly-developed macromolecular assembly that can incorporate hydrophilic compounds
三层聚合物胶束:一种新开发的大分子组装体,可以结合亲水性化合物
DOI: 10.1016/j.colsurfb.2010.03.047
发表时间: 2010
期刊: Colloids Surf. B : Biointerfaces
影响因子: --
作者: [Uchida, Y. and Y. Murakami]
通讯作者: Y. and Y. Murakami
バイオマテリアルとしての高分子ミセルの新展開~精密構造高分子が形成するゲル・粒子・シート状材料
聚合物胶束作为生物材料的新进展——由精确结构的聚合物形成的凝胶、颗粒和片状材料
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [R. J. Christie, K. Miyata, Y. Matsumoto, T. Nomoto, D. Menasco, T.-C. Lai, M. Pennisi, K. Osada, S. Fukushima, N. Nishiyama, Y. Yamasaki, K. Kataoka, 村上義彦]
通讯作者: 村上義彦
6
    海外基金