PART II: ANALYSIS OF PROTEIN TYROSINE SULFATION

第二部分：蛋白质酪氨酸硫酸化分析

• 批准号: 6220988
• 负责人: LI ZHANG
• 金额: $ 0.26万
• 依托单位: MELLON PITTS CORPORATION (MPC CORP)
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-08-01 至 2000-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6220988
• 关键词: biological products; biomedical resource; computers; musculoskeletal system; skeletal system

This proposal requests grant of computing time for the development and enhancement of the analytical capabilities needed to improve the understanding of the biomechanical-biological interactions that form the basis of the musculoskeletal system's adaption to its mechanical environment. The underbar multi-year projects which are currently in progress in which the analytical capabilities would be directly applied include the following: 1. An analysis of biomechanical factors influencing bone remodeling in a canine total hip replacement model. 2. To analyze factors influencing bone ingrowth into porous materials and the micromotion associated with elastic displacement incompatibilities at the interface between porous materials and the host bone. 3. To study adaptive bone remodeling with the help of computer simulations of bone-implant configuration and to find out specifically the consequence of the initial bone geometry and stiffness on adaptive response to the implant. 4. To study geometrical and physical factors that affect the life of an ultra high molecular polyethylene tibial component. 5. To study factors influencing strain and deformation both in the healthy and in the degenerated intervertebral motion segment of the lumber spine. Preliminary studies on these projects have been conducted with the help of finite element models on CRAY Y-MP at UIUC. They helped to understand the effect of some of the important variables on the biological problems considered. Studies have to be conducted on several other variables in all these projects before a clear understanding of the biomechanical-biological interactions can be understood.

该提案要求为开发提供计算时间 以及增强分析能力，以改善 对生物力学-生物相互作用的理解 肌肉骨骼系统适应其力学行为的基础 环境。目前正在实施的Underbar多年期项目 分析能力将直接 主要应用内容如下：1.生物力学分析 犬全髋关节置换术中骨改建的影响因素 模特。2.分析影响骨向多孔内生长的因素 材料和与弹性位移相关的微运动 多孔材料与材料之间界面的不相容 宿主骨。3.研究适应性骨改建。 骨-种植体结构的计算机模拟并找出 特别是初始骨骼几何形状的结果和 对植入物的适应性反应的刚性。4.学习 影响超高寿命的几何和物理因素 分子聚乙烯胫骨组件。5.研究影响因素 对健康人和老年人的应变和变形的影响 腰椎退变的椎间运动节段。 有关这些项目的初步研究已与 UIUC Cray Y-MP有限元模型的帮助。他们帮助我们 了解一些重要变量对 所考虑的生物问题。必须对以下问题进行研究： 所有这些项目中的其他几个变量在明确 对生物力学-生物相互作用的理解可以是 明白了。