EX VIVO MRM OF RENAL VASCULATURE IN POLYCYSTIC KIDNEY DISEASES

多囊肾疾病肾血管的离体 MRM

• 批准号: 6282361
• 负责人: DAVID D WOO
• 金额: $ 1.33万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 1999-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6282361
• 关键词: Mammalia; biomedical resource; magnetic resonance imaging; urinary tract

Progressive apoptotic loss of non-cystic nephons has recently been shown to be an important pathological feature associated with the development of polycystic kidney diseases (Woo, NEJM 333:18-25, 1995). In contrast to the high vascularized, blood red appearance of normal kidneys, end-stage polycystic kidneys from human patients and from animal models are pale and translucent and seldom bleed when punctured. I therefore reasoned that the renal vasculature must also be greatly abnormal and perhaps absent in end-stage polycystic kidneys. I propose to use ex-vivo magnetic resonance microscopy to characterize the renal vasculature of polycystic kidneys from two mutant mouse strains and one mutant rat strain that develop congenital polycystic kidney diseases. I estimate that imaging 4-5 normal and 4-5 polycystic kidneys at different stages of disease progression harvested from each of the three rodent models of polycystic kidney disease should provide a comprehensive picture of the fate of the renal vasculature in the development of polycystic kidney diseases in these models.

最近，非囊性肾细胞的进行性凋亡丢失被认为是 这是一个重要的病理特征， 多囊性肾病的发展（Woo，NEJM 333：18-25，1995）。 与正常的高血管化、血红色外观相反 肾脏，末期多囊肾从人类患者和从 动物模型是苍白和半透明的， 被刺穿了 因此，我推断肾血管系统也必须 在终末期多囊卵巢综合征中， 肾脏 我建议使用离体磁共振显微镜 多囊肾的肾血管系统的特点，从两个 突变小鼠品系和一种突变大鼠品系， 多囊肾病 我估计成像4-5正常， 4-5疾病进展不同阶段的多囊肾 从三种多囊性肾的啮齿动物模型中的每一种中收获 疾病应该提供一个全面的命运的图片， 多囊肾的发病与肾血管的关系 这些模型。