ARRHYTHMIAS & CHAOS

这个项目的目标是阐明调节 从以下三个方面着手防治心律失常：(1) 抗心律失常药物对心律失常影响的模拟研究 通过计算机建模，(2)开发精确的算法 这将使我们能够从单粒子中提取动力学参数 通道膜片钳记录，以及(3)表征新型 可能由细胞兴奋性引起的混乱。实现第一 目的，我们将研究Na+激动剂和拮抗剂的作用。 用计算机模拟和分叉的方法研究钙离子和钾离子通道 分析。这项研究将使我们能够找到导致 抗心律失常药物致心律失常作用及治疗建议 有效使用这些药物治疗心律失常。在第二个 方法，我们将通过结合以下方法来开发RaccurateS算法 用极大似然分析方法进行最大熵最大化。 使用这个算法，我们将阐明 心室肌细胞内的钙通道。要实现第三个 目的，我们将对可兴奋性进行分叉分析。 我们团队开发的细胞模型。这项研究将引导我们 与新类型的混沌有关的表征 心肌细胞和神经元。

The goal of this project is to elucidate the factors that modulate cardiac arrhythmias by working on the following three areas: (1) simulating the effect of antiarrhythmic drugs on cardiac arrhythmias by means of computer modelling, (2) developing Raccurate" algorithms which will allow us to extract the kinetic parameters from the single channel patch-clamp recordings, and (3) characterizing new types of chaos that may arise from cellular excitability. To achieve the first goal, we will study the effect of agonists and antagonists of Na+, Ca2+, and K+ channels by means of computer modelling and bifurcation analyses. This study will allow us to find the factors that cause the proarrhythmic effect by antiarrythmic drugs and suggest means to treat cardiac arrhythmicas effectively using these drugs. In the second approach, we will develop an RaccurateS algorithm by combining entropic maximization with the maximum-likelihood analysis method. Using this algorithm, we will elucidate the quantitative role of the Ca2+ channels in the ventricular cells. To achieve the third objective, we will carry out a bifurcation analysis on the excitable cell models developed by our group. This study will lead us the characterization of new types of chaos that are associated with cardiac cells and neurons.