VIRTUAL CELL MODELING OF CELL LOCOMOTION

细胞运动的虚拟细胞建模

• 批准号: 6123548
• 负责人: KEN JACOBSON
• 金额: $ 1.86万
• 依托单位: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 1999-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6123548
• 关键词: animal tissue; biomedical resource; model design /development

This is an excellent, well-funded project which would use the Virtual Cel1 to model cell locomotion. The fish scale keratocyte is used as the locomotion paradigm where the cell can move without shape change, thus allowing a simpler modeling. The forces at play on the cell during its locomotion have been mostly described: protrusion, adhesion and retraction. At least two of these can be accounted for by actin polymerization or depolymerization at the leading edge. This appears to be a good system for modeling since so many parameters are known. In fact, others have modeled motility with quite successful outcomes (e.g., Lauffenberger) and it has been useful for making predictions about cell behavior. This appears to be a very good application of the Virtual Cell approach. There may be some redundancy to work being done in other laboratories specifically focused on these questions as well.

这是一个优秀的，资金充足的项目，将使用 Virtual Cell 1模拟细胞运动。 鱼鳞角膜细胞是 用作运动范例，其中细胞可以无形状地移动 改变，从而允许更简单的建模。 在地球上起作用的力量 细胞在其运动过程中主要被描述为：突起， 粘附和回缩。 其中至少有两个可以解释 通过肌动蛋白聚合或解聚作用。 这 似乎是一个很好的系统建模，因为这么多的参数， 知道的 事实上，其他人已经建立了运动模型， 结果（例如，Lauffenberger），它对制造 预测细胞的行为。 这似乎是一个非常好的 采用虚拟小区的方法。 可能会有一些 其他实验室正在进行的工作的冗余， 也专注于这些问题。