课题基金 / 基金详情

RECOMBINANT ANTIBODIES BLOCKING SPOROZOITE TRANSMISSION

RECOMBINANT ANTIBODIES BLOCKING SPOROZOITE TRANSMISSION
阻断子孢子传播的重组抗体
批准号：
6040614
负责人：
Anthony A. James
金额：
$25.76万
依托单位：
UNIVERSITY OF CALIFORNIA-IRVINE
依托单位国家：
美国
项目类别：
财政年份：
2000
资助国家：
美国
项目状态：
已结题
起止时间：
2000-02-01 至 2003-01-31
来源：
https://reporter.nih.gov/project-details/6040614
关键词：
Aedes Coccidia Plasmodium arthropod borne communicable disease blocking antibody cell line chickens communicable disease control communicable disease transmission disease vectors gene expression genetic manipulation host organism interaction immunoglobulin structure malaria molecular cloning recombinant proteins spores transfection western blottings

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中文摘要
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英文摘要
DESCRIPTION (Adapted from the Applicant's Abstract): This is a 3 year revised application that proposes to provide a working model using antibodies, Fab's/F(ab')2's or scFvs to block sporozoite (from P. gallinaceum) invasion of salivary glands in mosquitoes (A. aegypti). The ultimate goal is to be able to insert genes for these scFv's into mosquitoes using recombinant methods so that the mosquitoes will not be suitable hosts for sporozoite invasion and transmission. The idea is that results from these research projects will be relatively easily transferred to the P. falciparum sporozoites and their vectors, anopholine mosquitoes.
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