RECOMBINANT ANTIBODIES BLOCKING SPOROZOITE TRANSMISSION
RECOMBINANT ANTIBODIES BLOCKING SPOROZOITE TRANSMISSION
批准号:
6349887
负责人:
Anthony A. James
金额:
$24.18万
依托单位国家:
美国
项目类别:
财政年份:
2000
资助国家:
美国
项目状态:
已结题
起止时间:
2000-02-01 至 2003-01-31
关键词:
Aedes Coccidia Plasmodium arthropod borne communicable disease blocking antibody cell line chickens communicable disease control communicable disease transmission disease vectors gene expression genetic manipulation host organism interaction immunoglobulin structure malaria molecular cloning recombinant proteins spores transfection western blottings
中文摘要
描述(改编自申请人的摘要):这是一个3年修订的
该申请提出提供使用抗体的工作模型,
Fab’s/F(ab’)2’s或scFv阻断子孢子(来自鸡疫霉)侵入
蚊子的唾液腺(A.埃及)。最终目标是能够
使用重组方法将这些scFv的基因插入蚊子中,
蚊子将不是子孢子侵入的合适宿主,
传输我们的想法是,这些研究项目的结果将
相对容易转移到恶性疟原虫子孢子及其
媒介,按蚊。
英文摘要
DESCRIPTION (Adapted from the Applicant's Abstract): This is a 3 year revised
application that proposes to provide a working model using antibodies,
Fab's/F(ab')2's or scFvs to block sporozoite (from P. gallinaceum) invasion of
salivary glands in mosquitoes (A. aegypti). The ultimate goal is to be able to
insert genes for these scFv's into mosquitoes using recombinant methods so that
the mosquitoes will not be suitable hosts for sporozoite invasion and
transmission. The idea is that results from these research projects will be
relatively easily transferred to the P. falciparum sporozoites and their
vectors, anopholine mosquitoes.
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会议论文
Nicking endonuclease-mediated gene drive in mosquitoes
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批准号:9045567
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项目类别:
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资助金额:$23.18万
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财政年份:2015
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负责人:Anthony A. James
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依托单位:
Nicking endonuclease-mediated gene drive in mosquitoes
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批准号:8849107
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项目类别:
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资助金额:$19.31万
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财政年份:2015
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负责人:Anthony A. James
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依托单位:
Mosquito innate immune responses to arbovirus infections
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批准号:8260248
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项目类别:
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资助金额:$22.58万
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财政年份:2011
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负责人:Anthony A. James
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依托单位:
Mosquito innate immune responses to arbovirus infections
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批准号:7675036
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项目类别:
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资助金额:$21.22万
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财政年份:2009
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负责人:Anthony A. James
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依托单位:
Pole cell isolation from the mosquitoes, Aedes aegypti and Anopheles stephensi
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批准号:7529894
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项目类别:
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资助金额:$19.06万
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财政年份:2008
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负责人:Anthony A. James
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依托单位:
Pole cell isolation from the mosquitoes, Aedes aegypti and Anopheles stephensi
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批准号:7620412
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项目类别:
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资助金额:$19.11万
-
财政年份:2008
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负责人:Anthony A. James
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依托单位:
RECOMBINANT ANTIBODIES BLOCKING SPOROZOITE TRANSMISSION
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批准号:6040614
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项目类别:
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资助金额:$25.76万
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财政年份:2000
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负责人:Anthony A. James
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依托单位:
RECOMBINANT ANTIBODIES BLOCKING SPOROZOITE TRANSMISSION
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批准号:6497133
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项目类别:
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资助金额:$24.9万
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财政年份:2000
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负责人:Anthony A. James
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依托单位:
Species-specific regulated transposition in mosquitoes
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批准号:6720574
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项目类别:
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资助金额:$37.57万
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财政年份:1998
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负责人:Anthony A. James
-
依托单位:
Species-specific regulated transposition in mosquitoes
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批准号:6992692
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项目类别:
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资助金额:$36.91万
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财政年份:1998
-
负责人:Anthony A. James
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依托单位:
HERMES AND MARINER TRANSFORMATION OF AEDES AEGYPTI
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批准号:6624543
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项目类别:
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资助金额:$34.15万
-
财政年份:1998
-
负责人:Anthony A. James
-
依托单位:
HERMES AND MARINER TRANSFORMATION OF AEDES AEGYPTI
-
批准号:6328808
-
项目类别:
-
资助金额:$32.19万
-
财政年份:1998
-
负责人:Anthony A. James
-
依托单位:
Species-specific regulated transposition in mosquitoes
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批准号:7146022
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项目类别:
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资助金额:$35.82万
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财政年份:1998
-
负责人:Anthony A. James
-
依托单位:
HERMES AND MARINER TRANSFORMATION OF AEDES AEGYPTI
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批准号:6124231
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项目类别:
-
资助金额:$28.02万
-
财政年份:1998
-
负责人:Anthony A. James
-
依托单位:
Species-specific regulated transposition in mosquitoes
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批准号:6828268
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项目类别:
-
资助金额:$37.67万
-
财政年份:1998
-
负责人:Anthony A. James
-
依托单位:
HERMES AND MARINER TRANSFORMATION OF AEDES AEGYPTI
-
批准号:6475527
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项目类别:
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资助金额:$33.16万
-
财政年份:1998
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负责人:Anthony A. James
-
依托单位:
Species-specific regulated transposition in mosquitoes
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批准号:7330341
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项目类别:
-
资助金额:$35.14万
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财政年份:1998
-
负责人:Anthony A. James
-
依托单位:
HERMES AND MARINER TRANSFORMATION OF AEDES AEGYPTI
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批准号:2742511
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项目类别:
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资助金额:$28.5万
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财政年份:1998
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负责人:Anthony A. James
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依托单位:
CONFERENCE ON TOWARD THE GENETIC MANIPULATION OF INSECTS
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批准号:2546875
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项目类别:
-
资助金额:$0.5万
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财政年份:1998
-
负责人:Anthony A. James
-
依托单位:
FLP-MEDIATED RECOMBINATION IN THE MOSQUITO AEDES AEGYPTI
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批准号:3147850
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项目类别:
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资助金额:$12.96万
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财政年份:1992
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负责人:Anthony A. James
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依托单位:
海外基金