Psychosis MRI Shared Data Resource (Psy-ShareD): Partnership Grant

精神分裂症和精神病影响了大约1%的个人；那些被确诊的人往往无法在社会上正常运作，因为目前的治疗选择在有效性上是有限的。精神分裂症引起幻觉和妄想，深刻影响个人的福祉，给患者和家人带来巨大的痛苦。尽管在了解精神分裂症的危险因素和大脑如何受到影响方面已经取得了一些进展，但我们仍然远不确定是什么原因导致了精神分裂症。现代脑扫描技术，如磁共振成像(MRI)，已经被用来研究精神分裂症患者大脑结构的不同，并投入了大量的研究时间和金钱。然而，这项研究的大部分是由个别研究小组在相对较少的患者身上进行的。精神分裂症的症状在不同的人之间有很大的不同，所以我们需要对大量的大脑扫描进行调查，以便得出可靠的结论。此外，我们还需要考虑疾病的所有阶段，还需要考虑高危个体的大脑结构差异，例如那些有精神分裂症家族史的人。这将使我们了解大脑中发生的变化，从而导致高度衰弱的精神病症状。为了实现这一点，我们需要结合之前大量脑扫描研究的数据，以便所有研究人员都可以访问来自不同人群的大量脑扫描数据，并对其进行分析。为了应对这些挑战，我们建议将世界各地研究人员收集的现有MRI扫描合并为一个免费可用的数据库资源(PSY共享)。扫描将是匿名的，这意味着患者将无法被识别。大脑扫描将有其他与之相关的信息，如症状信息和记忆/注意力测试的结果，这将帮助研究人员更多地了解精神错乱时大脑是如何受到影响的。该数据库将为许多研究精神分裂症的研究人员提供必要的资源，并允许其他人进行新的研究。这是迫切需要的，因为目前在英国或国际上都没有这种类型的数据库。PSY-Shared将向世界各地的所有研究人员开放，还将提供指导和教学材料，以特别帮助新手用户。在计划这项研究时，我们将让经历过精神病的人参与进来。我们会以最好的方式征询他们的意见，以确保数据包含在数据库中的患者的隐私，使用数据库的最佳方式，以及如何向其他研究人员和患者推广数据库。PSY-Shared通过允许所有机构和所有职业阶段的研究人员分析疾病阶段的高质量数据，具有影响研究的巨大潜力。这将导致在理解精神病患者的大脑中发生什么方面的重要见解和进展。除了最初用于建立PSY共享的2500次MRI扫描之外，我们还将积极寻找其他愿意在英国和海外捐赠他们的MRI数据的研究人员。我们将专门从能够提供非欧洲人群相关MRI数据集的国际联系人和合作者那里寻找MRI数据，以确保PSY共享更具代表性。此外，我们会进行一系列的宣传活动，并利用社交媒体渠道，以提高知名度和知名度。我们希望确保所有感兴趣的研究人员都知道PSY共享，确保这一新的宝贵资源得到充分利用。

Schizophrenia and psychotic illness affects approximately 1% of individuals; those diagnosed are often unable to function normally within society, as current treatment options are limited in their effectiveness. Schizophrenia causes hallucinations and delusions which profoundly impact the individual's wellbeing, causing huge suffering for patients and families. Although some progress has been made in terms of understanding risk factors and how the brain is affected in schizophrenia, we are still far from certain about what causes it. Modern brain scanning techniques such as Magnetic Resonance Imaging (MRI) have been used to study how the structure of the brain differs in schizophrenia, and much research time and money has been invested in this. However, most of this research has been conducted by individual research groups on relatively small numbers of patients. Schizophrenia symptoms vary a lot between individuals, so we need to run investigations across large numbers of brain scans in order to draw reliable conclusions. Also, we need to consider all stages of the disease, and also consider brain structural differences in individuals at high risk, such as those with a family history of schizophrenia. This will allow us to understand what changes occur in the brain, to cause the highly debilitating symptoms of psychosis. To achieve this, we need to combine data from a large number of previous brain scanning studies, so all researchers can access and conduct analyses on a large collection of brain scans drawn from a wide range of different people. To address these challenges we propose to combine existing MRI scans collected by researchers worldwide into one freely available database resource (Psy-ShareD). The scans will be anonymised meaning that patients won't be able to be identified. The brain scans will have other information linked to them such as symptom information and also results of memory/attention tests, which will help researchers understand more about how the brain is affected in psychosis. The database will provide an essential resource for many researchers who study schizophrenia and will allow others to undertake new research. It is sorely needed, as currently, no database of this type exists in the UK or internationally. Psy-ShareD will be accessible to all researchers around the world, guidance and instructional materials will also be made available, to help novice users in particular. We will involve people who have experienced psychosis when planning this research. We will seek their advice in the best way to ensure the privacy of patients whose data is included in the database, the best way to use the database and also how to promote the database to other researchers and patients. Psy-ShareD has large potential to impact research, by allowing researchers at all institutions, and at all career stages, to analyse high-quality data across disease stages. This will lead to important insights and progress in understanding what occurs in the brain in patients with psychosis. In addition to the initial 2,500 MRI scans used to establish Psy-ShareD, we will actively seek out other researchers willing to donate their MRI data in the UK and overseas. We will specifically seek MRI data from international contacts and collaborators that can provide relevant MRI datasets in non-European populations, to ensure Psy-ShareD is more representative. Also, we will undertake a range of promotional activities, and make use of social media channels, to maximise visibility and uptake. We want to make sure that all interested researchers know about Psy-ShareD, ensuring this new and valuable resource gets fully utilised.