TRAINING IN CARTILAGE RESEARCH

软骨研究培训

• 批准号: 2909771
• 负责人: KLAUS E KUETTNER
• 金额: --
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-05-01 至 2001-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2909771
• 关键词: TRAINING; CARTILAGE; RESEARCH

This revised application for a training grant outlines the educational and training facilities in the Department of Biochemistry. Through its close interaction with members of the Department of Orthopaedic Surgery and the Section of Rheumatology and the renewal of the sole NIH-SCOR grant in osteoarthritis, a significant segment of the faculty is dedicated to basic researching the field of connective tissue and cartilage biochemistry, as it relates to arthritic conditions, especially osteoarthritis (OA). This has led to a major commitment to training predoctorate (Ph.D.) candidates and postdoctorate fellows, who carry out under the guidance of a faculty member research in this and other medically relevant areas. In the rebuttal to the review of the original application, it is pointed out that the Ph.D. training program combines a standard regimen of coursework in basic biochemistry with emphasis on medical relevance, as well as specialized courses in connective tissue (cartilage) biochemistry. Since the initiation of the Ph.D. program in 1984, 26 candidates have received their Ph.D. degrees; 12 of them presented their dissertation in the field of connective tissue (cartilage) biochemistry. The current 26 Ph.D. students actively participate in weekly departmental workshops and interact with nationally and internationally recognized experts in cartilage research, who are invited bi-monthly to the Department. (8 of them have not chosen their advisors yet; among the remaining, 14 have selected a Ph.D.-advisor from the faculty involved in connective tissue/cartilage research). Through this redrafted application, financial support is sought for three students per year for 5 years (equal 43 student-years). The training program for postdoctorate fellows has a select focus on cartilage biochemistry and osteoarthritis based on an assignment by the World Health Organization. It has provided training for 44 postdoctorate fellows from around the globe. Currently 10 fellows are working in the Department (about 50% of past or current fellows hold the M.D. degree). Each postdoctorate fellow is assigned to a faculty member, but broader education is facilitated through the weekly workshops, formal seminars, interactive discussions with visiting scientists and informal discussion groups. The postdoctorate training program enables the fellows to become active members of an investigative team, to learn the design of individual research strategies, to expand their professional goals, to monitor and teach graduate and medical school classes and to develop their writing skills from publications and grants. It allows them, as they enter the scientific work force, to make meaningful contributions to cartilage biochemistry. For the next five years, financial support is sought to pay for two postdoctorate fellowships per year (equal 10 fellowship-years). This training program is unique in preparing, side by side, graduate students and postdoctorate fellows for research careers. This new NIH Training Grant will enable the training program to focus on musculoskeletal investigations, especially cartilage biochemistry and the etiopathology of OA.

这项修订的培训申请概述了教育和 生物化学系的培训设施。 通过它的结束 与骨科手术部成员的互动和 风湿病学部分和唯一的NIH-SCOR赠款的更新 骨关节炎，该教师的重要部分致力于基本 研究结缔组织和软骨生物化学的领域， 它与关节炎疾病有关，尤其是骨关节炎（OA）。 这 导致了对培训前（博士）候选人的重大承诺 和后者的研究员，他们在教职员工的指导下进行 成员研究该领域和其他与医学相关的领域。 在 反驳原始申请的审查，请指出 博士培训计划结合了课程的标准方案 基本的生物化学，重点是医学相关性 结缔组织（软骨）生物化学的专门课程。 自博士学位启动以来1984年的计划，有26名候选人 获得博士学位学位；他们中的12个介绍了他们的论文 结缔组织（软骨）生物化学领域。 当前26 博士学生积极参加每周的部门研讨会和 与国家和国际认可的专家互动 软骨研究，每两月邀请到该部门。 （8 他们尚未选择顾问。在其余14个 从涉及结缔组织的教职员工中选择了博士学位 组织/软骨研究）。 通过此重新起草的应用程序，财务 每年为5年寻求三名学生的支持（等于43 学生年）。 博士后研究员的培训计划针对 软骨生物化学和骨关节炎是基于 世界卫生组织。 它为44个术后提供了培训 来自全球的研究员。 目前有10名研究员正在工作 部门（约有50％的过去或当前研究员拥有医学博士学位）。 每个胜利的研究员都被分配给教职员工，但更广泛 通过每周研讨会，正式研讨会，教育是促进教育的 与访问科学家的互动讨论和非正式讨论 组。 博士后训练计划使研究员成为 调查团队的活跃成员，学习个人的设计 研究策略，扩大其专业目标，监视和 教授研究生和医学院课程并发展他们的写作 出版物和赠款的技能。 当他们进入 科学劳动力，为软骨做出有意义的贡献 生物化学。 在接下来的五年中，寻求经济支持 对于每年两次偷策后奖学金（等于10年度奖学金）。 该培训计划在并排准备工作方面是独一无二的 学生和博士后研究员的研究职业。 这个新的NIH 培训赠款将使培训计划能够专注于肌肉骨骼 调查，特别是软骨生物化学和病理学 OA。