TRAINING IN CARTILAGE RESEARCH

软骨研究培训

• 批准号: 2909771
• 负责人: KLAUS E KUETTNER
• 金额: --
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-05-01 至 2001-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2909771
• 关键词: TRAINING; CARTILAGE; RESEARCH

This revised application for a training grant outlines the educational and training facilities in the Department of Biochemistry. Through its close interaction with members of the Department of Orthopaedic Surgery and the Section of Rheumatology and the renewal of the sole NIH-SCOR grant in osteoarthritis, a significant segment of the faculty is dedicated to basic researching the field of connective tissue and cartilage biochemistry, as it relates to arthritic conditions, especially osteoarthritis (OA). This has led to a major commitment to training predoctorate (Ph.D.) candidates and postdoctorate fellows, who carry out under the guidance of a faculty member research in this and other medically relevant areas. In the rebuttal to the review of the original application, it is pointed out that the Ph.D. training program combines a standard regimen of coursework in basic biochemistry with emphasis on medical relevance, as well as specialized courses in connective tissue (cartilage) biochemistry. Since the initiation of the Ph.D. program in 1984, 26 candidates have received their Ph.D. degrees; 12 of them presented their dissertation in the field of connective tissue (cartilage) biochemistry. The current 26 Ph.D. students actively participate in weekly departmental workshops and interact with nationally and internationally recognized experts in cartilage research, who are invited bi-monthly to the Department. (8 of them have not chosen their advisors yet; among the remaining, 14 have selected a Ph.D.-advisor from the faculty involved in connective tissue/cartilage research). Through this redrafted application, financial support is sought for three students per year for 5 years (equal 43 student-years). The training program for postdoctorate fellows has a select focus on cartilage biochemistry and osteoarthritis based on an assignment by the World Health Organization. It has provided training for 44 postdoctorate fellows from around the globe. Currently 10 fellows are working in the Department (about 50% of past or current fellows hold the M.D. degree). Each postdoctorate fellow is assigned to a faculty member, but broader education is facilitated through the weekly workshops, formal seminars, interactive discussions with visiting scientists and informal discussion groups. The postdoctorate training program enables the fellows to become active members of an investigative team, to learn the design of individual research strategies, to expand their professional goals, to monitor and teach graduate and medical school classes and to develop their writing skills from publications and grants. It allows them, as they enter the scientific work force, to make meaningful contributions to cartilage biochemistry. For the next five years, financial support is sought to pay for two postdoctorate fellowships per year (equal 10 fellowship-years). This training program is unique in preparing, side by side, graduate students and postdoctorate fellows for research careers. This new NIH Training Grant will enable the training program to focus on musculoskeletal investigations, especially cartilage biochemistry and the etiopathology of OA.

这份修订后的培训补助金申请概述了教育和 生物化学系的培训设施。通过它的收盘 与骨科和骨科成员的互动 风湿科和#年唯一的NIH-SCOR补助金的续期 骨性关节炎，相当一部分教职员工致力于基础 研究结缔组织和软骨生物化学领域，如 它与关节炎有关，尤其是骨关节炎(OA)。这 已经导致了对博士研究生(博士)培养的重大承诺。候选人 和博士后研究员，他们在教员的指导下进行 会员在这一领域和其他医学相关领域的研究。在 反驳了对原申请的审查，指出 博士培训计划结合了标准的课程方案 基础生物化学，强调医学相关性，以及 结缔组织(软骨)生物化学专业课。 自1984年博士项目启动以来，已有26名考生 获得博士学位；其中12人在年提交了论文 结缔组织(软骨)生物化学领域。目前的26个 博士生积极参加每周一次的部门工作坊和 与国内和国际公认的专家互动 软骨研究，他们每两个月被邀请到系。(第8页，共 他们还没有选择他们的顾问；在剩下的14个人中，已经选择了 从参与Connective的教职员工中选择了一名博士导师 组织/软骨研究)。通过这份重新起草的申请，金融 5年内每年资助3名学生(相当于43名) 学生年)。 针对博士后研究员的培训计划有选择地侧重于 软骨生物化学和骨关节炎 世界卫生组织。已为44名博士后提供了培训 来自世界各地的人。目前有10名研究员在 系(约50%的前任或现任研究员拥有医学博士学位)。 每个博士后研究员分配给一名教职员工，但范围更广 通过每周讲习班、正式研讨会、 与来访的科学家进行互动讨论和非正式讨论 组。博士后培训计划使研究员能够成为 积极的调查团队成员，学习个人的设计 研究战略，以扩大他们的专业目标，以监测和 教授研究生和医学院的课程并培养他们的写作能力 来自出版物和赠款的技能。它允许他们在进入 科技工作者，为软骨事业做出有意义的贡献 生物化学。在接下来的五年里，寻求财政支持来支付 每年获得两个博士后奖学金(相当于10个奖学金年)。 这一培训计划在并排准备毕业生方面是独一无二的 学生和博士后研究员的研究生涯。这个新的美国国立卫生研究院 培训补助金将使培训方案能够专注于肌肉骨骼 研究，特别是软骨生物化学和发病机制 骨关节炎。