Training in Cartilage Research

软骨研究培训

• 批准号: 7637973
• 负责人: Theodore Richard Oegema
• 金额: $ 18.76万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7637973
• 关键词: Cartilage; Research; Training

DESCRIPTION (provided by applicant): This is a competitive continuation application for a training grant entitled, "Training in Cartilage Research. This application outlines the participating faculty as well as the educational and training facilities, primarily in the Department of Biochemistry. A core of Program Faculty members is dedicated to basic research in the field of cartilage and connective tissue biochemistry as well as chondrocyte cell and molecular biology as it relates to arthritic diseases, especially osteoarthritis (OA). There is a strong interaction with faculty in the Departments of Orthopedic Surgery, Anatomy & Cell Biology, and the Section of Rheumatology. The NIH SCOR grant in OA, NIH R01 grants and interactions with pharmaceutical companies provide much of the research support to the Program Faculty. There is an active collaboration with the Gift of Hope Organ and Tissue Donor Network to obtain normal human cartilage on a weekly basis. There is a major commitment by the Program Faculty to train predoctoral students and postdoctoral fellows in the areas of chondrocyte gene expression and regulation, cartilage imaging, matrix assembly, degradation and repair, mechanisms of action of growth factors and cytokines, cell-matrix interactions via receptors, models for chondrocyte and cartilage culture, differences between human articular cartilage derived from different joints and different regions of cartilage, as well as animal models for degenerative joint diseases. Most students pursue a PhD in Biochemistry and in addition to rigorous research training, obtain a broad scientific background with the advent of a new Graduate College core curriculum. Each student and postdoctoral fellow has a faculty mentor, but broader education is facilitated through weekly workshops, formal seminars, informal discussion groups/lab meetings and interactions with visiting scientists from other academic, research and industry-based institutions. For the next five years, financial support is sought for three postdoctoral fellowships per year and stipends for five predoctoral students who have completed their preliminary examinations. The continuation of this unique NIH Training Grant will enable a training program that combines education in basic medical biochemistry with musculoskeletal research investigations, especially cartilage biochemistry, chondrocyte molecular and cell biology and, the etiopathology of OA. In line with the NIH roadmap, our trainees will be in excellent positions to translate basic cartilage research into new patient treatments.

描述（由申请人提供）：这是一个竞争性的培训补助金申请，题为“软骨研究培训”。该申请概述了参与的教师以及主要在生物化学系的教育和培训设施。项目的核心成员致力于软骨和结缔组织生物化学以及软骨细胞和分子生物学领域的基础研究，因为它与关节炎疾病，特别是骨关节炎（OA）有关。与骨科外科、解剖学和细胞生物学以及风湿病学部门的教师有很强的互动。美国国立卫生研究院在OA中的SCOR拨款，美国国立卫生研究院R01拨款以及与制药公司的互动为项目教师提供了大量的研究支持。我们与“希望的礼物”器官和组织捐赠网络积极合作，每周获得正常的人体软骨。该项目主要致力于培养博士生和博士后，研究领域包括：软骨细胞基因表达和调控、软骨成像、基质组装、降解和修复、生长因子和细胞因子的作用机制、通过受体的细胞-基质相互作用、软骨细胞和软骨培养模型、来自不同关节和不同区域的人类关节软骨的差异、以及退化性关节疾病的动物模型。大多数学生攻读生物化学博士学位，除了严格的研究训练外，还可以通过研究生院新的核心课程获得广泛的科学背景。每个学生和博士后都有一位教师导师，但更广泛的教育是通过每周的研讨会、正式研讨会、非正式讨论小组/实验室会议以及与来自其他学术、研究和行业机构的访问科学家的互动来促进的。今后5年，每年为3名博士后提供资助，并为完成初试的5名博士生提供津贴。这项独特的NIH培训补助金的延续将使培训计划能够将基础医学生物化学教育与肌肉骨骼研究调查相结合，特别是软骨生物化学，软骨细胞分子和细胞生物学以及OA的病因病理学。根据美国国立卫生研究院的路线图，我们的学员将处于优秀的位置，将基础软骨研究转化为新的患者治疗。