ADRENERGIC CONTROL OF CENTRAL SYMPATHETIC ACTIVITY

中枢交感神经活动的肾上腺素控制

• 批准号: 6125813
• 负责人: ANTONIO R GRANATA
• 金额: $ 24.93万
• 依托单位: NEW YORK MEDICAL COLLEGE
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-01-25 至 2001-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6125813
• 关键词: autonomic reflex; brain mapping; cardiovascular function; electrophysiology; essential hypertension; laboratory rat; medulla oblongata; neurogenic hypertension; neuroregulation; norepinephrine; sympathetic nervous system; vascular smooth muscle nervous control

This proposal seeks a better understanding of how sympathetic cardiovascular and vasomotor activity is generated and, hence, how cardiovascular function is regulated by the central nervous system. The long goals of these studies are (1) to know more about the normal physiology of the autonomic nervous system in order to improve our understanding of many autonomic imbalances secondary to other pathologies, e.g., congestive heart failure, shock, etc., and (2) to gain a better approach to the physiopathology and treatment of essential and neurogenic hypertension. Neurons in the rostral ventrolateral medulla (RVLM) are critically involved in the tonic and reflex control of the circulation. These neurons are able to be characterized because: a) they receive baro- and mechanoreceptor inputs, b) they project to the sympathetic spinal cord, c) they are most probably the origin of the tonic vasomotor activity, and d) they mediate the baro- and other mechanoreflex responses. The major aim of this proposal is to test the hypothesis that the activity f a characterized group of RVLM-spinal neurons, responsible for generating tonic and reflex sympathetic cardiovascular activity is modulated by projections originating in the contralateral RVLM. Using an intracellular recording technique in vivo, we have identified different types of RVLM neurons with electrophysiological and cardiovascular (barosensitive) characteristics and projections to the sympathetic spinal cord. Study I in this proposal is designed to provide with new significant data to anatomically characterize the interconnecting pathways between both RVLMs. This information will further support Study II that is designed to test a model of sympathetic cardiovascular regulation incorporating the reciprocal innervation of RVLM neurons. This research will produce evidence that synaptic inputs (excitatory or inhibitory) received from the opposite RVLM neurons. We will further investigate the hypothesis that these presumed inputs are conveyed by projections originating in C1 adrenergic neurons located in the opposite RVLM. Overall, these studies will provide new information about the neuronal mechanisms in the RVLM involved in the tonic and reflex control of cardiovascular function, particularly the possible role played by the reciprocal RVLM adrenergic projections.

这项提议寻求更好地理解人们对 心血管和血管运动活动是如何产生的，因此， 心血管功能由中枢神经系统调节。这个 这些研究的长期目标是(1)更多地了解常态 自主神经系统的生理学，以改善我们的 对许多继发于其他病理的自主神经失衡的理解， 例如充血性心力衰竭、休克等，以及(2)获得更好的 高血压性神经源性疾病的生理病理及治疗探讨 高血压。延髓头端腹外侧区(RVLM)内的神经元 在血液循环的紧张性和反射控制方面起关键作用。 这些神经元之所以能够被定性，是因为：a)它们接受压力- 和机械感受器输入，b)它们投射到交感神经脊髓 C)它们很可能是紧张性血管舒缩剂的起源 活动，以及d)它们调节压力反射和其他机械反射反应。 这一提议的主要目的是检验这样一种假设，即 F一组特征性的RVLM-脊髓神经元，负责产生 紧张性和反射性交感心血管活动受 投射起源于对侧RVLm。使用细胞内 在活体记录技术中，我们已经鉴定了不同类型的RVLM 具有电生理和心血管(压力敏感)功能的神经元 交感神经脊髓的特点和投射。研究I在 该提案旨在提供新的重要数据，以 从解剖学角度描述两个RVLM之间的相互连接路径。 这些信息将进一步支持旨在测试 交感神经心血管调节模型 RVLM神经元的相互神经支配。这项研究将产生 有证据表明，突触传入(兴奋性或抑制性)来自 与RVLM神经元相对。我们将进一步调查这一假设 这些假定的输入由起源于c1的投影来传达 肾上腺素能神经元位于对侧RVLM。总体而言，这些研究 将提供有关RVLM中神经机制的新信息 参与心血管功能的紧张性和反射控制， 尤其是相互作用的RVLm肾上腺素能 投射。