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ADRENERGIC CONTROL OF CENTRAL SYMPATHETIC ACTIVITY

中枢交感神经活动的肾上腺素控制

基本信息

批准号：
6330109
负责人：
ANTONIO R GRANATA
金额：
$ 25.68万
依托单位：
NEW YORK MEDICAL COLLEGE
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
起止时间：
1999-01-25 至 2003-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6330109
关键词：
autonomic reflex brain mapping cardiovascular function electrophysiology essential hypertension laboratory rat medulla oblongata neurogenic hypertension neuroregulation norepinephrine sympathetic nervous system vascular smooth muscle nervous control

项目摘要

This proposal seeks a better understanding of how sympathetic cardiovascular and vasomotor activity is generated and, hence, how cardiovascular function is regulated by the central nervous system. The long goals of these studies are (1) to know more about the normal physiology of the autonomic nervous system in order to improve our understanding of many autonomic imbalances secondary to other pathologies, e.g., congestive heart failure, shock, etc., and (2) to gain a better approach to the physiopathology and treatment of essential and neurogenic hypertension. Neurons in the rostral ventrolateral medulla (RVLM) are critically involved in the tonic and reflex control of the circulation. These neurons are able to be characterized because: a) they receive baro- and mechanoreceptor inputs, b) they project to the sympathetic spinal cord, c) they are most probably the origin of the tonic vasomotor activity, and d) they mediate the baro- and other mechanoreflex responses. The major aim of this proposal is to test the hypothesis that the activity f a characterized group of RVLM-spinal neurons, responsible for generating tonic and reflex sympathetic cardiovascular activity is modulated by projections originating in the contralateral RVLM. Using an intracellular recording technique in vivo, we have identified different types of RVLM neurons with electrophysiological and cardiovascular (barosensitive) characteristics and projections to the sympathetic spinal cord. Study I in this proposal is designed to provide with new significant data to anatomically characterize the interconnecting pathways between both RVLMs. This information will further support Study II that is designed to test a model of sympathetic cardiovascular regulation incorporating the reciprocal innervation of RVLM neurons. This research will produce evidence that synaptic inputs (excitatory or inhibitory) received from the opposite RVLM neurons. We will further investigate the hypothesis that these presumed inputs are conveyed by projections originating in C1 adrenergic neurons located in the opposite RVLM. Overall, these studies will provide new information about the neuronal mechanisms in the RVLM involved in the tonic and reflex control of cardiovascular function, particularly the possible role played by the reciprocal RVLM adrenergic projections.

这一建议旨在更好地理解如何同情心血管和血管活动的产生，因此，心血管功能受中枢神经系统调节。的这些研究的长期目标是（1）了解更多关于正常自主神经系统的生理学，以改善我们的了解许多继发于其他病理的自主神经失衡，例如，在一个实施例中，充血性心力衰竭、休克等，（2）获得更好的原发性和神经源性脑血管病的病理生理学和治疗方法高血压延髓头端腹外侧区（RVLM）的神经元与循环的紧张和反射控制密切相关。这些神经元能够被表征是因为：a）它们接收压力，和机械感受器输入，B）它们投射到交感脊髓 c）它们最有可能是紧张性血管紧张素的起源活动，和d）它们介导压力和其他机械反射反应。本提案的主要目的是检验活动 f一组特征性RVLM-脊髓神经元，负责产生紧张性和反射性交感心血管活动由起源于对侧RVLM的投射。使用细胞内记录技术在体内，我们已经确定了不同类型的RVLM 神经元与电生理和心血管（压力敏感）特征和对交感神经脊髓的投射。研究I，本提案旨在提供新的重要数据，在解剖学上表征两个RVLM之间的互连通路。这些信息将进一步支持研究II，该研究旨在测试交感心血管调节模型， RVLM神经元的相互神经支配。这项研究将产生证据表明，突触输入（兴奋性或抑制性）收到的与RVLM神经元相反。我们将进一步研究假设，这些假定的输入由源自C1的投影传送肾上腺素能神经元位于对侧RVLM。总的来说，这些研究将为RVLM的神经机制提供新的信息参与心血管功能的紧张和反射控制，特别是相互的RVLM肾上腺素能神经元预测。