CLOZAPINE AND SKILL TRAINING FOR SCHIZOPHRENIA

氯氮平与精神分裂症技能培训

• 批准号: 6185518
• 负责人: THOMAS E SMITH
• 金额: $ 16.25万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-05-01 至 2001-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6185518
• 关键词: antipsychotic agents; attention deficit disorder; behavioral /social science research tag; chronic disease /disorder; clinical research; clinical trials; clozapine; combination therapy; drug screening /evaluation; human subject; human therapy evaluation; interview; longitudinal human study; memory disorders; mental disorder chemotherapy; neuropsychology; psychobiology; psychotherapy; remedial /special education; schizophrenia; sign /symptom; social adjustment; training; verbal learning

The objective of this Clinical Mental Health Academic Award application is to assist Dr. Thomas Smith in his academic activities in the field of schizophrenia and to develop a schizophrenia clinical research program at The New York Hospital Cornell Medical Center, Westchester Division. The primary focus of this program will be to investigate factors that influence recovery and community reintegration of treatment refractory schizophrenic patients. The development plan described in this application outlines a program of tutorials/seminars, consultations with notable scholars, and feasibility studies that will allow Dr. Smith to become an academic resource and rigorous clinical investigator. The award will free Dr. Smith from most of his present responsibilities and permit him to: a) develop skills in the assessment of psychotic symptoms and neuropsychological deficits in schizophrenic patients; b) become an expert in the assessment and treatment of social skill deficits commonly seen in chronically psychotic patients; and c) conduct a research project studying the combined effects of the atypical antipsychotic medication clozapine and a manualized symptom management social skills training program on symptom control, social skill, and social adjustment in a cohort of treatment refractory schizophrenic patients. With this training Dr. Smith will assume an important role in the Cornell University Medical College Department of Psychiatry as an expert regarding the assessment and treatment of refractory schizophrenia. Given the severity of this illness, the strong desire of patients and their families for active, community- based treatment, and the current economic constraints that potentially limit the availability and quality of care for schizophrenia, the development of Dr. Smith as an academic resource leading a sophisticated clinical research program will have important long-term benefits. Dr. Smith will function as an educator and mentor to junior faculty interested in pursuing research in schizophrenia, and will organize courses and seminars for medical students, psychiatric residents and psychology interns at Cornell University Medical College. Academic and research activities will take place throughout the award period. As a result of these efforts, hypotheses regarding the underlying relationships between psychotic symptoms, neuropsychological deficits, learning capacity, and social adjustment in schizophrenia will be formulated. After the award period Dr. Smith will become a recognized researcher in the treatment of chronic schizophrenia and function as a faculty scholar, fostering the career development of medical students, residents, fellows and colleagues.

临床心理健康学术奖的目的是 协助托马斯·史密斯博士在该领域的学术活动 精神分裂症，并制定一项精神分裂症临床研究计划， 纽约医院康奈尔医疗中心，韦斯特切斯特分部。的 该计划的主要重点将是调查因素， 难治性影响康复和重返社区 精神分裂症患者本申请书所述的发展计划 概述了教程/研讨会计划，与著名的 学者，和可行性研究，将使史密斯博士成为一个 学术资源和严谨的临床研究者。该奖项将免费 博士史密斯先生目前的大部分职责，并允许他：a） 发展评估精神病症状的技能， 精神分裂症患者的神经心理缺陷; B）成为专家 在评估和治疗常见的社会技能缺陷， 长期精神病患者;及c）进行一项研究计划， 非典型抗精神病药物氯氮平 和一个手动的症状管理社交技能培训计划， 症状控制、社会技能和社会适应在一个队列中的应用 治疗难治性精神分裂症患者。通过这次培训，史密斯博士 将在康奈尔大学医学院担任重要角色 精神科作为专家进行评估， 治疗难治性精神分裂症鉴于这种疾病的严重性， 患者及其家属对积极的、社区的强烈愿望， 基础治疗，以及目前的经济限制， 限制精神分裂症护理的可用性和质量， 史密斯博士的发展作为一个学术资源，领导一个复杂的 临床研究计划将具有重要的长期效益。博士 史密斯将作为一个教育工作者和导师感兴趣的初级教师 进行精神分裂症的研究，并将组织课程， 为医科学生、精神科住院医生和心理学人员举办的研讨会 康奈尔大学医学院的实习生学术和研究 活动将在整个颁奖期间举行。的结果 这些努力，假设之间的潜在关系， 精神病症状，神经心理缺陷，学习能力，和 精神分裂症的社会适应将被制定。获奖后 史密斯博士将成为公认的研究人员在治疗 慢性精神分裂症和功能作为一个教师学者，培养 医学生、住院医生、研究员和同事的职业发展。

项目成果

Symptoms and neurocognition as rate limiters in skills training for psychotic patients.

症状和神经认知作为精神病患者技能培训的速率限制因素。

• DOI: 10.1176/ajp.156.11.1817
• 发表时间: 1999
• 期刊: The American journal of psychiatry.
• 作者: Smith,TE;Hull,JW;Romanelli,S;Fertuck,E;Weiss,KA
• 通讯作者: Weiss,KA

The relative influences of symptoms, insight, and neurocognition on social adjustment in schizophrenia and schizoaffective disorder.

• DOI: 10.1097/00005053-199902000-00006
• 发表时间: 1999-02
• 期刊: The Journal of nervous and mental disease
• 作者: Thomas E. Smith;James W. Hull;Marianne Goodman;A. Hedayat-Harris;D. Willson;Lyssa M. Israel;Richard L. Munich

Interactive risk factors for treatment adherence in a chronic psychotic disorders population.

慢性精神障碍人群治疗依从性的交互危险因素。

• DOI: 10.1016/s0165-1781(99)00111-0
• 发表时间: 1999
• 期刊: Psychiatry research
• 影响因子: 11.3
• 作者: Corriss,DJ;Smith,TE;Hull,JW;Lim,RW;Pratt,SI;Romanelli,S
• 通讯作者: Romanelli,S

Dimensions of social adjustment in schizophrenia: a factor analysis.

精神分裂症社会适应的维度：因素分析。

• DOI: 10.1097/00005053-199901000-00010
• 发表时间: 1999
• 期刊: The Journal of nervous and mental disease
• 作者: Smith,TE;Hull,JW;Clarkin,JF
• 通讯作者: Clarkin,JF

Insight and recovery from psychosis in chronic schizophrenia and schizoaffective disorder patients.

慢性精神分裂症和分裂情感障碍患者精神病的洞察力和康复。

• DOI: 10.1016/s0022-3956(03)00091-8
• 发表时间: 2004
• 期刊: Journal of psychiatric research
• 影响因子: 4.8
• 作者: Smith,ThomasE;Hull,JamesW;Huppert,JonathanD;Silverstein,StevenM;Anthony,DonnaT;McClough,JoelF
• 通讯作者: McClough,JoelF