CLOZAPINE AND SKILL TRAINING FOR SCHIZOPHRENIA

氯氮平与精神分裂症技能培训

• 批准号: 2415799
• 负责人: THOMAS E SMITH
• 金额: $ 15.3万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-05-01 至 2001-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2415799
• 关键词: antipsychotic agents; attention deficit disorder; behavioral /social science research tag; chronic disease /disorder; clinical research; clinical trials; clozapine; combination therapy; drug screening /evaluation; human subject; human therapy evaluation; interview; longitudinal human study; memory disorders; mental disorder chemotherapy; neuropsychology; psychobiology; psychotherapy; remedial /special education; schizophrenia; sign /symptom; social adjustment; training; verbal learning

The objective of this Clinical Mental Health Academic Award application is to assist Dr. Thomas Smith in his academic activities in the field of schizophrenia and to develop a schizophrenia clinical research program at The New York Hospital Cornell Medical Center, Westchester Division. The primary focus of this program will be to investigate factors that influence recovery and community reintegration of treatment refractory schizophrenic patients. The development plan described in this application outlines a program of tutorials/seminars, consultations with notable scholars, and feasibility studies that will allow Dr. Smith to become an academic resource and rigorous clinical investigator. The award will free Dr. Smith from most of his present responsibilities and permit him to: a) develop skills in the assessment of psychotic symptoms and neuropsychological deficits in schizophrenic patients; b) become an expert in the assessment and treatment of social skill deficits commonly seen in chronically psychotic patients; and c) conduct a research project studying the combined effects of the atypical antipsychotic medication clozapine and a manualized symptom management social skills training program on symptom control, social skill, and social adjustment in a cohort of treatment refractory schizophrenic patients. With this training Dr. Smith will assume an important role in the Cornell University Medical College Department of Psychiatry as an expert regarding the assessment and treatment of refractory schizophrenia. Given the severity of this illness, the strong desire of patients and their families for active, community- based treatment, and the current economic constraints that potentially limit the availability and quality of care for schizophrenia, the development of Dr. Smith as an academic resource leading a sophisticated clinical research program will have important long-term benefits. Dr. Smith will function as an educator and mentor to junior faculty interested in pursuing research in schizophrenia, and will organize courses and seminars for medical students, psychiatric residents and psychology interns at Cornell University Medical College. Academic and research activities will take place throughout the award period. As a result of these efforts, hypotheses regarding the underlying relationships between psychotic symptoms, neuropsychological deficits, learning capacity, and social adjustment in schizophrenia will be formulated. After the award period Dr. Smith will become a recognized researcher in the treatment of chronic schizophrenia and function as a faculty scholar, fostering the career development of medical students, residents, fellows and colleagues.

本临床心理健康学术奖申请的目的是 协助托马斯·史密斯博士在该领域的学术活动 精神分裂症并制定精神分裂症临床研究计划 纽约医院康奈尔医学中心威彻斯特分部。这 该计划的主要重点是调查影响因素 影响难治性患者的康复和重新融入社区 精神分裂症患者。本申请中描述的开发计划 概述了一个教程/研讨会计划，与著名人士的咨询 学者和可行性研究将使史密斯博士成为一名 学术资源和严谨的临床研究者。该奖项将免费 史密斯博士免除了目前的大部分职责，并允许他：a) 培养评估精神病症状的技能 精神分裂症患者的神经心理缺陷； b) 成为专家 评估和治疗常见的社交技能缺陷 慢性精神病患者； c) 开展研究项目 非典型抗精神病药物氯氮平的综合作用 以及手动症状管理社交技能培训计划 一组患者的症状控制、社交技能和社会适应 治疗难治性精神分裂症患者。通过这次培训史密斯博士 将在康奈尔大学医学院担任重要角色 精神病学系作为专家进行评估和 治疗难治性精神分裂症。鉴于这种疾病的严重性， 患者及其家属积极参与社区活动的强烈愿望 基础治疗以及当前的经济限制可能会 限制精神分裂症护理的可用性和质量， 史密斯博士作为学术资源的发展引领着复杂的 临床研究计划将产生重要的长期效益。博士。 史密斯将担任感兴趣的初级教师的教育者和导师 致力于精神分裂症的研究，并将组织课程和 为医学生、精神病住院医师和心理学举办的研讨会 康奈尔大学医学院实习生。学术与研究 活动将在整个颁奖期间进行。后果 这些努力、关于之间潜在关系的假设 精神病症状、神经心理缺陷、学习能力和 将制定精神分裂症的社会适应措施。颁奖后 在此期间，史密斯博士将成为治疗以下疾病方面公认的研究员 慢性精神分裂症并担任教师学者，培养 医学生、住院医生、研究员和同事的职业发展。