Acquiring rich longitudinal passive sleep data across childhood and adolescence (8-18yrs)-the AMBIENT sleep study

获取童年和青春期（8-18 岁）丰富的纵向被动睡眠数据 - AMBIENT 睡眠研究

• 批准号: MR/X028917/1
• 负责人: Heather Whalley
• 金额: $ 19.22万
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FX028917%2F1
• 关键词: Acquiring; rich; longitudinal; passive; sleep

Sleep is an essential part of health, allowing individuals to function at their best. It is widely reported that many children and teens do not get enough sleep, putting them at greater risk of various negative health and educational outcomes. However, these links have yet to be fully investigated. For example, during the key developmental stages of childhood and adolescence (8-18years), sleep behaviours change significantly. Despite this, we do not know what constitutes normal changes in sleep patterns, what are potentially problematic, or indicate underlying current or future problems, and what external factors may be influencing changes.Current data collection methods have various problems. Sleep can be measured in detail using polysomnography, however this is not possible to use this long-term and at-scale. Subjective self-report questionnaire data, or sleep diaries, though possible to conduct at scale, have been shown to be unreliable. Measures derived from research quality sleep-wake watches (actigraphs), are a more objective way of gathering data, however, they are not always well tolerated. Based on our own experience of actigraphy in young people in our award (Sleep, circadian rhythms and mental health in schools (SCRAMS) project), this technique presented two main issues (i) low tolerance, especially in people with hyper touch sensitivity or movement limitation and (ii) limited by battery life and data storage, restricting its period of use. Difficulties are also reported in other studies: both UK Biobank and ABCD (large studies on 10s of thousands of people) administered actigraphy, but only short time durations (a few weeks at most). Such short recordings are not appropriate for understanding sleep behavior in depth, as the effects of weekends, school holidays or seasonal changes are not represented. During our SCRAMS focus groups, pupils identified other problems with actigraphy: (i) a few days were required to get used to it, (ii) uncomfortable/bulky to wear, (iii) strap sometimes caused dry skin/rash, and (iv) easy to forget to put back on after bathing/swimming. Thus, 18% of our participants did not wear the actigraph for the study duration. Teacher feedback indicated dropping out was higher in pupils from vulnerable groups or with lower academic performance. Similar bias in terms of those who did not complete data collection are reported in other studies like UB Biobank. There is therefore an urgent need for new ways to collect sleep data that are easier to use and over longer periods of time and that can lessen these biases.We propose to develop and evaluate a new way of collecting sleep data that requires no active participation once installed. We will test a non-wearable sleep tracker that uses radar-based sleep monitoring in the home. Somnofy (VitalThings, Norway) is a commercially available sleep monitor that has been validated against PSG and undergone relevant safety approvals. The system can be used over relatively long periods of time and has the potential to be used at scale. We will optimize methods across the ages 8-18yrs to test feasibility and performance against standard methods of sleep data collection. We will co-produce materials with young people in order that research can be made accessible, engaging, and relevant across the different age ranges and backgrounds. We will invite them to either join our product review group, or our citizen science group, to engage them in the research.We will therefore develop protocols and analysis approaches that facilitate the use of these new generation of sleep data collection methods at scale in future longitudinal adolescent cohort studies. These methods can then be used to address questions around how patterns change over critical developmental windows, what reflects normal sleep behaviours, what potentially predicts negative outcomes, and what may be protective for sleep health

睡眠是健康的重要组成部分，它能让人在最佳状态下工作。据广泛报道，许多儿童和青少年睡眠不足，使他们面临各种负面健康和教育结果的更大风险。然而，这些联系尚未得到充分调查。例如，在儿童和青少年（8-18岁）的关键发育阶段，睡眠行为会发生显著变化。尽管如此，我们不知道是什么构成了睡眠模式的正常变化，什么是潜在的问题，或表明潜在的当前或未来的问题，以及什么外部因素可能会影响变化。目前的数据收集方法存在各种问题。睡眠可以用多导睡眠图详细测量，但不可能长期和大规模地使用这种方法。主观自我报告问卷调查数据，或睡眠日记，虽然可能进行大规模，已被证明是不可靠的。从研究质量的睡眠-觉醒表（活动记录仪）中得出的测量方法是一种更客观的收集数据的方法，然而，它们并不总是被很好地接受。根据我们自己在获奖项目（学校睡眠、昼夜节律和心理健康（SCRAMS）项目）中对年轻人的活动描记术的经验，该技术存在两个主要问题：(i)耐受性低，特别是在触摸超敏感或运动受限的人群中；（ii）受电池寿命和数据存储的限制，限制了其使用时间。其他研究也报告了困难：UK Biobank和ABCD（对成千上万人进行的大型研究）都进行了活动描记术，但持续时间很短（最多几周）。这样短的记录不适合深入了解睡眠行为，因为周末、学校假期或季节变化的影响没有得到体现。在我们的SCRAMS焦点小组中，学生们发现了活动记录仪的其他问题：(i)需要几天的时间来适应它，（ii）佩戴不舒服/笨重，（iii）皮带有时会导致皮肤干燥/皮疹，（iv）洗澡/游泳后容易忘记戴上。因此，18%的参与者在研究期间没有佩戴活动记录仪。教师的反馈表明，弱势群体或学习成绩较差的学生退学的比例更高。在其他研究中，如UB Biobank，报告了未完成数据收集的人的类似偏倚。因此，我们迫切需要一种新的方法来收集睡眠数据，这种方法更容易使用，时间更长，可以减少这些偏见。我们建议开发和评估一种收集睡眠数据的新方法，一旦安装，就不需要积极参与。我们将测试一种非穿戴式睡眠追踪器，它在家中使用基于雷达的睡眠监测。Somnofy （VitalThings, Norway）是一款市面上可买到的睡眠监测仪，已经通过了针对PSG的验证，并通过了相关的安全认证。该系统可以在相对较长的时间内使用，并且具有大规模使用的潜力。我们将优化年龄在8-18岁之间的方法，以测试标准睡眠数据收集方法的可行性和性能。我们将与年轻人共同制作材料，以便研究可以在不同的年龄范围和背景下进行，具有吸引力和相关性。我们会邀请他们加入我们的产品评审小组，或者我们的公民科学小组，让他们参与到研究中来。因此，我们将开发协议和分析方法，以促进在未来的纵向青少年队列研究中大规模使用这些新一代睡眠数据收集方法。然后，这些方法可以用来解决以下问题：在关键的发育窗口期，模式是如何变化的，什么反映了正常的睡眠行为，什么可能预测负面结果，以及什么可能保护睡眠健康