Can we heal people using electricity? Developing fundamental understanding and bioelectronic devices to exploit bioelectricity in bioengineering.

我们可以用电来治愈人们吗？

• 批准号: MR/X032159/1
• 负责人: Stuart Higgins
• 金额: $ 180.89万
• 依托单位: University of York
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2024
• 资助国家: 英国
• 起止时间: 2024 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FX032159%2F1
• 关键词: heal; people; using; electricity; Developing

Bioelectricity is the presence and movement of electrical charges inside living organisms. It plays a critical role in the operation and regulation of life and is responsible for many fascinating natural phenomena. However, it remains one of the least well understood aspects of life. Much of the scientific research has evolved into separate fields. We're familiar with pacemakers that help regulate electrical signals within the heart, but perhaps less aware of the role electric fields play in helping guide cells to heal our wounds or regulate the size of our organs during our fundamental development. In some areas of research, our experiments are comparable to Luigi Galvani's work placing wires in frogs' legs, back in the late 1700s.Joined up thinking about bioelectricity, combining insights from multiple research disciplines is needed, along with better experimental techniques. At the same time, our new tools must be able to contextualise the role of bioelectricity alongside all the other factors that influence living cell and tissue behaviour (for example, external forces and the patterns of different biologically active molecules).This project will establish new methods for developing our understanding of bioelectricity. It will do this by building intricate bioelectronic devices that reflect the complexity of biological and bioengineering problems by incorporating many inputs and measuring many outputs at once. At the same time, it will also provide a network for bringing bioengineers, developmental biologists, biophysicists, and clinicians to further investigate the role of bioelectricity together.

生物电是生物体内电荷的存在和运动。它在生命的运作和调节中发挥着至关重要的作用，并导致许多令人着迷的自然现象。然而，它仍然是生活中最不为人所知的方面之一。许多科学研究已经发展到不同的领域。我们熟悉起搏器，它有助于调节心脏内的电信号，但可能不太了解电场在帮助引导细胞愈合伤口或在我们的基本发育过程中调节器官大小方面所发挥的作用。在某些研究领域，我们的实验可与 1700 年代末 Luigi Galvani 在青蛙腿中放置电线的工作相媲美。需要联合思考生物电、结合多个研究学科的见解以及更好的实验技术。与此同时，我们的新工具必须能够将生物电的作用与影响活细胞和组织行为的所有其他因素（例如外力和不同生物活性分子的模式）结合起来。该项目将为加深我们对生物电的理解建立新的方法。它将通过构建复杂的生物电子设备来实现这一目标，这些设备通过合并许多输入并同时测量许多输出来反映生物和生物工程问题的复杂性。同时，它还将提供一个网络，将生物工程师、发育生物学家、生物物理学家和临床医生聚集在一起，进一步研究生物电的作用。