EARLY DEVELOPMENT, AGING AND NEURODEGENERATION

描述：(摘自申请)：最近的数据导致了 认为许多基因与阿尔茨海默病和其他疾病有关 神经退行性疾病是在早期发挥作用的相同基因。 神经系统的发育和正常衰老。早期现象 神经系统包括神经细胞的死亡，细胞骨架的改变 伴随着神经细胞轴突和树突的生长和退化 以及突触接触的改变。尽管这些概括具有 变得明显起来，还有很多事情是未知的。表达的细节是如何 衰老和神经退行性疾病的图谱与图谱不同 在细胞分裂、细胞凋亡和轴突萌发过程中表达？ 分子级联中的这些差异是如何受差异影响的？ 在大脑发育和老化所提供的环境之间？什么是 这些差异在基因表达谱上的功能后果是什么？ 我们建议召开一次研讨会，将来自酵母的各种专业知识汇聚在一起 对人类来说，从最初的细胞分裂到细胞死亡，从实验台到 临床检查细胞适应的分子机制，这是 在早期发育、正常衰老和年龄相关性神经退行性变中常见 以阿尔茨海默病为重点的疾病。这些专家将成为 被赋予交换信息的任务，并在出版物中 提出与上述问题相关的假设并提出策略 用于批判性研究来检验这些假说。参与者将包括 顶尖科学家：来自国内外大学和 行业；研究员；研究生和一群精挑细选的高级 学校重视少数族裔学生的参与。这个 研讨会将于2000年8月24日至28日在罗切斯特大学的AAB举行 位于康贝格医学研究大楼的生物医学科学研究所。

DESCRIPTION: (abstract from the application): Recent data have led to the concept that many of the genes involved in Alzheimer's disease and other neurodegenerative diseases are the same genes that play a role in the early development and normal aging of the nervous system. Phenomena of early nervous system include death of nerve cells, alterations of the cytoskeleton with accompanying growth and regression of nerve cell axons and dendrites as well as alterations in synaptic contacts. Although these generalizations have become apparent, much remains unknown. How do the details of expression profiles in aging and neurodegenerative disease differ from the profiles expressed during cell division, during apoptosis and during neurite sprouting? How are these differences in molecular cascades influenced by differences between the milieu offered by the developing and the aging brain? What are the functional consequences of these difference, in profiles of gene expression? We propose a symposium that will bring together expertise ranging from yeast to human, from initial cell division to cell death and from the lab bench to the clinic to examine molecular mechanisms of cellular adaptations that are common among early development, normal aging and age_related neurodegenerative disease with an emphasis on Alzheimer's disease. These experts will be presented with the task of exchanging information, and, in a publication formulating hypotheses related to the above questions and proposing strategies for critical studies to test these hypotheses. Participants will include leading scientists: from domestic and international universities and industries; fellows; graduate students and a group of highly selected high school students with an emphasis on minority student participation. The symposium will be held August 24_28, 2000 at the University of Rochester's Aab Institute for Biomedical Science located in Komberg Medical Research Building.