EARLY DEVELOPMENT, AGING AND NEURODEGENERATION

描述：（应用程序摘要）：最近的数据导致 许多与阿尔茨海默病和其他疾病有关的基因 神经退行性疾病是相同的基因，发挥作用，在早期 神经系统的发育和正常衰老。早期现象 包括神经细胞的死亡，细胞骨架的改变 伴随着神经细胞轴突和树突的生长和退化， 以及突触接触的改变。虽然这些概括具有 变得明显，许多仍然未知。细节如何表达 在衰老和神经退行性疾病中的特征不同于 在细胞分裂，凋亡和神经突发芽过程中表达？ 分子级联中的这些差异是如何受到差异的影响的 大脑发育和衰老的环境之间的关系有哪些 这些差异的功能后果，在基因表达谱？ 我们提议召开一次研讨会， 从最初的细胞分裂到细胞死亡， 临床检查细胞适应的分子机制， 常见于早期发育、正常衰老和与年龄相关的神经退行性疾病 疾病，重点是阿尔茨海默病。这些专家将 提出了交换信息的任务，并在出版物中 提出与上述问题相关的假设并提出策略 进行批判性研究来检验这些假设。与会者将包括 领先的科学家：来自国内和国际大学， 行业;研究员;研究生和一群经过精心挑选的高 学校的学生，重点是少数民族学生的参与。的 研讨会将于2000年8月24日至28日在罗切斯特大学的Aab举行 生物医学科学研究所位于Komberg医学研究大楼。

DESCRIPTION: (abstract from the application): Recent data have led to the concept that many of the genes involved in Alzheimer's disease and other neurodegenerative diseases are the same genes that play a role in the early development and normal aging of the nervous system. Phenomena of early nervous system include death of nerve cells, alterations of the cytoskeleton with accompanying growth and regression of nerve cell axons and dendrites as well as alterations in synaptic contacts. Although these generalizations have become apparent, much remains unknown. How do the details of expression profiles in aging and neurodegenerative disease differ from the profiles expressed during cell division, during apoptosis and during neurite sprouting? How are these differences in molecular cascades influenced by differences between the milieu offered by the developing and the aging brain? What are the functional consequences of these difference, in profiles of gene expression? We propose a symposium that will bring together expertise ranging from yeast to human, from initial cell division to cell death and from the lab bench to the clinic to examine molecular mechanisms of cellular adaptations that are common among early development, normal aging and age_related neurodegenerative disease with an emphasis on Alzheimer's disease. These experts will be presented with the task of exchanging information, and, in a publication formulating hypotheses related to the above questions and proposing strategies for critical studies to test these hypotheses. Participants will include leading scientists: from domestic and international universities and industries; fellows; graduate students and a group of highly selected high school students with an emphasis on minority student participation. The symposium will be held August 24_28, 2000 at the University of Rochester's Aab Institute for Biomedical Science located in Komberg Medical Research Building.