CONFERENCE--MECHANISMS OF CELL DEATH

我们请求资金支持将在西班牙马德里附近的埃尔埃斯科里亚修道院举行的第三届细胞死亡问题会议。这次会议的主题是“细胞维持和细胞死亡”。作为动态平衡概念的推论，因为它与细胞数量有关：在有丝分裂=细胞死亡的方程式中，方程式的两边都可能受到调节，这种调节对我们的健康和福祉至关重要。本次会议确认了细胞死亡协会目前的国际影响力，该协会自1995年以来已发展到400多名订阅成员。会议在非年度举行，避免与Keystone、Gordon和冷泉港会议发生冲突。我们关注整个生命中细胞死亡的更广泛的方面，保持对自然发生的细胞死亡在发育、分化、生育、衰老和疾病中的重要性和机制的兴趣。我们强调淋巴细胞凋亡与发生在神经元或其他组织以及发育和衰老之间的异同，包括信号机制、细胞内定位和易位以及半胱氨酸天冬氨酸酶和其他蛋白酶。我们强调失败在几种疾病情况下的影响，并将不同组织中的信号机制进行比较，如胸腺细胞、中枢和外周神经元、恶性细胞和病毒基因控制下的细胞。我们将重点放在过程上，要求来自几个学科的演讲者和与会者关注共同的元素，并注意重点如何不同，例如，神经元、胸腺细胞和其他类型的细胞，以及发育、衰老和病理。这次会议将迫使比较细胞支持机制和细胞破坏机制，提出何时缺乏细胞支持足以诱导细胞凋亡，何时需要积极信号自毁的问题。应外国追随者的要求，我们决定将会议转移到西班牙举行这次研讨会。埃尔埃斯科里亚尔修道院提供便利的交通以及一流的住宿和设施，是在对几个可能的地点进行审查后选择的。

We request funds to support the 3rd biannual Conference on Cell Death, to be held at El Escorial Monastery, near Madrid, Spain. The theme of the conference will be "Cell Maintenance and Cell Death". As our corollary of the concept of homeostasis as it pertains to cell number: in the equation mitosis=cell death, both sides of the equation may be regulated, and this regulation is vital for our health and well-being. This meeting recognizes the now international reach of the Cell Death Society which has grown since 1995 to over 400 subscribing members. The meeting falls in the off- year avoiding conflicts with the Keystone, Gordon, and Cold Spring Harbor meetings. We focus on the broader aspects of cell death throughout life, maintaining an interest in the importance and mechanism of natural occurrence of cell death in development, differentiation, fertility, and aging as well as disease. We emphasize the similarities and differences between paradigmatic lymphocyte apoptosis and that occurring in neurons or in other tissues and development and aging, examining signaling mechanisms, intracellular location and translocation, and caspases and other proteases. We emphasize the impact of failure in several disease situations, and we draw parallels among the signaling mechanisms in tissues as diverse as thymocytes, central and peripheral neurons, malignant cells, and cells under the control of viral genes. We focus on processes, asking the speakers and attendees from several disciplines to pay attention to common elements and to note how emphases can differ for instance, among neurons, thymocytes, and other types of cells, and among development, aging, and pathology This conference will force the comparison of cell-supportive mechanisms and cell-destructive mechanisms, raising questions of when absence of cell support is sufficient to induce apoptosis and when positive signals to self- destruct is needed. Following requests from our foreign adherents, we elected to move the meeting to Spain for this symposium. The El Escorial Monastery provides a combination of easy access plus excellent accommodations and facilities and was selected after a review of several possible sites.