Meeting: Mechanisms of Cell Death

描述（由申请人提供）：本申请申请资助将于2004年6月25日至28日在爱尔兰国立大学Maynooth学院举行的第五届细胞死亡双年会。会议的主题是“细胞维持与细胞死亡——展望21世纪”。程序性细胞死亡和凋亡的相关领域在许多学科中都很重要，包括免疫学、肿瘤学、神经学、传染病、心肌梗死和中风、生殖生物学、致畸学和环境医学。我们社会的一个主要目标是作为在这些学科之间保持富有成效和协同对话的手段。我们希望在这次会议上关注细胞死亡的阈值，特别是在可选择其他死亡途径（细胞凋亡、自噬和其他途径）的情况下。我们将继续关注过程，特别是与潜在的治疗用途以及由此产生的实验室和临床数据的解释有关的过程。我们将讨论诸如非半胱天冬酶蛋白酶在替代死亡途径中的作用，以及在萎缩和其他无死亡细胞退化中的作用，以及在诸如眼睛之类的器官中的作用，这些问题通常在会议上不被考虑。我们在发言者的种族和性别分配平等以及满足具体需要方面有着良好的记录，并将采取直接步骤继续和加强这一记录。我们在这些会议上也有很好的记录，支持和推荐即将到来的年轻科学家，他们不经常面对面。我们保持低成本以鼓励年轻科学家的参与。这次会议将把美国人和主要来自欧洲和中东的科学家聚集在一起。我们从这些会议中出版了两份《纽约科学院年鉴》，最后一次会议作为组织第二版《当细胞死亡》（Wiley-Liss）的基础。我们期待这次会议将产生更多的出版物。

DESCRIPTION (provided by applicant): This application requests funds to support the 5th Biannual Conference on Cell Death, to be held at Maynooth College, National University of Ireland, June 25-28 2004. The theme of the conference will be "Cell Maintenance and Cell Death -- a Look into the 21st Century". The related fields of programmed cell death and apoptosis are important in several disciplines, including immunology, oncology, neurology, infectious diseases, cardiac infarct and stroke, reproductive biology, teratology, and environmental medicine. A major goal of our society is to serve as a means of maintaining a fruitful and synergistic dialog among these disciplines. We expect to focus in this conference on thresholds at which cells commit to death, particularly in situations in which alternative paths to death (apoptosis, autophagy, and other paths) are options. We will maintain focus on processes, particularly insofar as they relate to potential therapeutic uses and interpretations of laboratory and clinical data deriving therefrom. We will address such issues as the roles of non-caspase proteases in alternative paths to death and in atrophy and other cell regression without death, and in organs such as the eye, which are not usually considered in meetings. We have an excellent record of equality in ethnic and gender distribution among speakers, as well as accommodation for specific needs, and will take direct steps to continue and enhance this record. We also have an excellent record of supporting and featuring upcoming junior scientists at these meetings, who do not often meet face to face. We keep our costs low to encourage participation by junior scientists. This conference will bring together Americans and scientists predominantly from Europe and the Middle East. We have published two Annals of the New York Academy of Sciences from these meetings, and the last meeting served as a basis for the organization of the second edition of When Cells Die (Wiley-Liss). We expect that this meeting will lead to further publications.