Scientific Meeting: Mechanisms of Cell Death

描述(由申请者提供)：我们请求资金支持将于2006年6月2日至5日在巴西安格拉多斯雷斯举行的第六届细胞死亡会议。这次会议的主题是“衰老、癌症和免疫相关疾病中的细胞周期和细胞死亡”。程序性细胞死亡和细胞凋亡在免疫学、肿瘤学、神经病学、传染病、心肌梗死和中风、生殖生物学、畸胎学和环境医学等多个学科中都很重要。我们社会的一个主要目标是在这些学科之间保持富有成效的和协同的对话。在这次会议中，我们将集中讨论细胞周期的改变以及细胞死亡、诱导和存活的机制。我们与会议相关的培训课程将介绍关于细胞周期、细胞死亡和衰老的主要最新发现。我们将讨论细胞周期和细胞死亡途径的机制，并将其与年龄相关的病理学联系起来，如神经退行性疾病和心血管疾病、细胞周期和癌症。我们将继续关注这些发现用于治疗的潜力以及实验室和临床数据的关系。对细胞凋亡的敏感性通常与细胞周期和生长因子的存在与否密切相关，这两个因素都随着年龄的变化而变化；细胞只有在适当的生理时间死亡的能力是增生性和退行性衰老疾病的主要因素。我们在发言者的种族和性别分布方面的平等记录非常出色(今年估计为三分之一)，我们对特定需求的适应也是如此。我们将采取直接措施继续并提高这一记录。我们在支持和介绍即将到来的初级科学家参加这些会议方面也有很好的记录。这次会议将是聚集来自美国、欧洲和南美的科学家的独特机会。我们已经从这些会议中出版了两本《纽约科学院年鉴》，最后一次会议是组织第二版《当细胞死亡》(Wiley-Liss)的基础。我们期待这次会议将产生更多的出版物。我们目前正在就出版安排进行谈判。NIH的资金将用于支持扬声器和设施。计划未来在法国和中国举行会晤。

DESCRIPTION (provided by applicant): We request funds to support the 6th Biannual Conference on Cell Death, to be held at Angra dos Reis, Brazil June 02-05 2006. The theme of the conference will be "Cell Cycle and Cell Death in Aging, Cancer and Immune Related Diseases". Programmed cell death and apoptosis are important in several disciplines, including immunology, oncology, neurology, infectious diseases, cardiac infarct and stroke, reproductive biology, teratology, and environmental medicine. A major goal of our society is to maintain a fruitful and synergistic dialog among these disciplines. In this conference we will focus on cell cycle alterations and the mechanisms of cell death induction and survival. Our meeting-associated training course will introduce the main recent findings on Cell Cycle, Cell Death and Aging. We will address and correlate the mechanisms of cell cycle and cell death pathways with age-related pathologies, such as neurodegenerative and cardiovascular diseases, cell cycle and cancer. We will maintain focus on the potential of these findings for therapy and the relationship of laboratory to clinical data. Sensitivity to apoptosis is frequently tightly linked to both cell cycle and the presence or absence of growth factors, both of which vary strongly with age; and the ability of cells to die only at appropriate physiological times is a major factor of both proliferative and degenerative diseases of aging. Our record of equality in ethnic and gender distribution among speakers is excellent (estimated 1/3 this year), as is our accommodation for specific needs. We will take direct steps to continue and enhance this record. We also have an excellent record of supporting and featuring upcoming junior scientists at these meetings. This conference will be a unique opportunity to gather scientists from the USA, Europe and South America. We have published 2 Annals of the New York Academy of Sciences from these meetings, and the last meeting served as a basis for the organization of the second edition of When Cells Die (Wiley-Liss). We expect that this meeting will lead to further publications. We are currently negotiating publication arrangements. NIH funds will be used to support speakers and facilities. Future meetings in France and China are planned.