Signaling and Therapeutics in Cell Death and Survival

细胞死亡和存活的信号传导和治疗

• 批准号: 8005302
• 负责人: ZAHRA ZAKERI
• 金额: $ 1.7万
• 依托单位: QUEENS COLLEGE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8005302
• 关键词: Address; Aging; Antiviral Agents; Apoptosis; Apoptotic; Area; Autophagocytosis; Cardiology; Cardiovascular Diseases; Cell Death; Cells; Chemicals; Chile; Collaborations; Commit; Country; Developed Countries; Developing Countries; Disease; Drug Industry; Educational workshop; Funding; Future; Home environment; Immunity; Immunology; International; Knowledge; Lead; Malignant Neoplasms; Mentors; Minority; Mitochondria; Necrosis; Neurodegenerative Disorders; Neurologic; Neurology; Pathway interactions; Plants; Published Comment; Request for Applications; Research; Research Personnel; Resort; Schedule; Science; Scientist; Senior Scientist; Signal Transduction; South America; South American; Students; Therapeutic; Time; Translational Research; Translations; Woman; Work; anticancer research; cancer cell; improved; insight; interest; meetings; public health relevance; rapid growth; research and development; symposium; trend

DESCRIPTION (provided by applicant): This application requests funds to support the International Conference on Cell Death, to be held at the hotel Marbella resort Maitencillo, Chile http://www.marbella.cl/ing/home.php, January 7-10, 2011. The title of the conference will be "Signaling and Therapeutics in Cell Death and Survival", but we will also include sessions addressing cell death in the most important diseases in developed countries. The meeting will focus on primary mechanisms of inducing and avoiding cell death (apoptosis, autophagy, and necrosis). Most of the speakers, including many of the most prominent theoreticians of cancer research will address the topic from the viewpoint of understanding malignancy. This meeting traditionally has been held in various countries to encourage more scientific exchanges than are possible in the US; the meetings have been well received by both participating US scientists and local scientists and students. We chose Chile to capture the rapid growth of science and pharmaceutical industries in South America and to encourage the translation of the mechanisms of cell death into therapies. Many unique species of South American plants potentially harbor antiviral and anticancer chemicals. Chile has embarked on a campaign to improve its intellectual and technical standing In comparison with other developing countries Chile spends proportionately more on R&D than other South American countries, including 30% women researchers but it is more economical and efficient for Western scientists to go to South America to interact with scientists in their home terrain. This meeting will encourage future collaborative work and exchanges in this research area. We will discuss the means by which the decision of a cell to die is modulated and triggered, how cells commit to autophagic, apoptotic or necrotic pathways and what decides the choice. These topics are of interest to aging, immunology, neurology, cardiology and specifically cancer. Our Women Mentoring Workshop has been very successful and popular with our attendees. Dr Eileen White will be the keynote speaker and will lead a panel discussion with an international cast. The full meeting will include sessions on alternative pathways to cell death; on cancer, immunity, aging and cell death; on neurological and cardiovascular diseases and cell death; mitochondria and cell death; and special talks of new forms of cell death. Talks by junior and senior scientists will be interspersed and will include a high percentage of women and minority speakers (41%) and chairs (67%). The schedule allows ample time for formal and informal discussions and socializing. An important aspect of our meetings has been a wrap-up talk, which summarizes the major new findings, traces emerging trends, and provides guidance for future trends. The wrap-up will be given by Mauro Piacentini, a prominent researcher in the area of cancer and cell death and who is exceptional at this task. PUBLIC HEALTH RELEVANCE: This meeting brings together experts from around the world to discuss the basic and translational science of cell death-apoptosis, autophagy, and other mechanisms-as it relates to cancer, aging, and neurodegenerative disease. In addition to the knowledge and insight gained, this meeting should stimulate exchanges and international collaboration, which themselves should widen the horizons for new discovery.

描述（由申请人提供）：本申请申请资金用于支持将于2011年1月7日至10日在智利马贝拉度假酒店Maitencillo http://www.marbella.cl/ing/home.php举行的细胞死亡国际会议。会议的标题将是“细胞死亡和生存中的信号和治疗”，但我们也将包括讨论发达国家最重要疾病中的细胞死亡的会议。会议将集中讨论诱导和避免细胞死亡的主要机制（凋亡、自噬和坏死）。大多数演讲者，包括许多最杰出的癌症研究理论家，将从理解恶性肿瘤的角度来讨论这个话题。这个会议传统上在不同的国家举行，以鼓励比美国更多的科学交流；会议受到与会的美国科学家和当地科学家和学生的好评。我们选择智利是为了抓住南美洲科学和制药工业的快速增长，并鼓励将细胞死亡机制转化为治疗方法。许多独特种类的南美植物潜在地含有抗病毒和抗癌的化学物质。与其他发展中国家相比，智利在研发方面的支出比例高于其他南美国家，其中包括30%的女性研究人员，但是对西方科学家来说，去南美与本国的科学家互动更为经济和有效。本次会议将鼓励未来在这一研究领域的合作和交流。我们将讨论细胞死亡的决定是如何被调节和触发的，细胞如何进入自噬、凋亡或坏死的途径，以及是什么决定了这种选择。这些课题对衰老、免疫学、神经学、心脏病学，特别是癌症都很有兴趣。我们的女性导师工作坊非常成功，受到与会者的欢迎。艾琳·怀特博士将担任主讲人，并将与国际演员进行小组讨论。全体会议将包括关于细胞死亡的替代途径的会议；癌症、免疫、衰老和细胞死亡；关于神经和心血管疾病和细胞死亡；线粒体与细胞死亡；还有关于细胞死亡新形式的特别演讲。初级和高级科学家的演讲将穿插其间，并将包括高比例的女性和少数民族演讲者（41%）和主席（67%）。日程安排为正式和非正式的讨论和社交活动提供了充足的时间。我们会议的一个重要方面是总结谈话，总结主要的新发现，追踪新趋势，并为未来趋势提供指导。Mauro Piacentini是癌症和细胞死亡领域的杰出研究人员，他在这项任务中表现出色。