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BARRIERS TO ANTI-INFLAMMATORY USE IN CHILDHOOD ASTHMA

儿童哮喘使用抗炎药的障碍

基本信息

批准号：
6135433
负责人：
HANNELORE YOOS
金额：
$ 7.96万
依托单位：
UNIVERSITY OF ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2000
资助国家：
美国
起止时间：
2000-03-01 至 2002-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6135433
关键词：
adolescence (12-20) antiinflammatory agents asthma behavioral /social science research tag belief clinical research health behavior health services research tag human subject middle childhood (6-11) parent offspring interaction psychometrics self care therapy compliance

项目摘要

Hospitalization rates, morbidity, and mortality from childhood asthma continue to increase despite scientific advances that have improved our understanding of the pathophysiology of asthma and the availability of more effective therapy for its management. Inhaled corticosteroids are considered to be the mainstay of pharmacological treatment for persistent asthma. However, there is a growing body of literature documenting under utilization of anti-inflammatories by patients. The reasons for this are unclear. Before interventions to enhance appropriate anti-inflammatory use can be designed and tested, we need to know more about the barriers to their use and have a psychometrically sound instrument to measure them. The overall aim of this study is to identify barriers to appropriate anti-inflammatory use in childhood asthma and to develop an instrument that may be useful in both research and health care settings to identify at risk populations and circumstances. The specific aims are: are: 1) to identify the domains of parental beliefs and attitudes related to anti-inflammatory use in their children with asthma; 2) to develop and test a questionnaire that reflects the beliefs and attitudes affecting anti-inflammatory use that is reliable and valid. The sample will consist of 109 parents of children with moderate to severe asthma who are currently enrolled in two clinical trials evaluating symptom perceptual accuracy and symptom monitoring strategies. Extensive demographic and disease related data is available for this population of children. We will collect data for instrument development in 4 phases: 1) Identification of potential domains of barriers to anti-inflammatory use: The professional perspective, 2) Content validation: Gaining the parent perspective, 3) Pre-testing and refinement of the Instrument, 4) Pilot testing. We will use classic psychometric techniques for tool development and testing.

尽管科学进步提高了我们对哮喘病理生理学的了解，并提供了更有效的治疗方法，但儿童哮喘的住院率、发病率和死亡率仍在继续增加。吸入性皮质类固醇被认为是持续性哮喘的主要药物治疗。然而，有越来越多的文献记载了患者对抗炎药的利用。其原因尚不清楚。在设计和测试加强适当抗炎使用的干预措施之前，我们需要更多地了解使用这些药物的障碍，并有一种心理测量学上健全的仪器来测量它们。本研究的总体目标是确定儿童哮喘中适当抗炎使用的障碍，并开发一种在研究和医疗保健环境中可能有用的工具，以识别高危人群和环境。具体目标是：为：1）确定与哮喘儿童抗炎药使用相关的父母信念和态度的领域; 2）开发并测试一份问卷，该问卷反映了影响抗炎药使用的信念和态度，该问卷是可靠和有效的。样本将包括109名中重度哮喘儿童的父母，他们目前参加了两项临床试验，评估症状感知准确性和症状监测策略。可获得这一儿童群体的大量人口统计学和疾病相关数据。我们将分4个阶段收集仪器开发的数据：1）识别抗炎用途：的潜在障碍领域：专业视角，2）内容验证：获得母公司视角，3）仪器的预测试和改进，4）中试测试。我们将使用经典的心理测量技术进行工具开发和测试。