STRESS, CORTISOL, AND COGNITIVE FUNCTION
压力、皮质醇和认知功能
基本信息
- 批准号:6085466
- 负责人:
- 金额:$ 3.53万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1999
- 资助国家:美国
- 起止时间:1999-11-01 至 2001-10-31
- 项目状态:已结题
- 来源:
- 关键词:attention behavioral /social science research tag biomarker clinical research cognition cortisol female hippocampus hormone biosynthesis hormone regulation /control mechanism human subject long term memory memory disorders performance physiologic stressor psychological tests secretion short term memory stress women's health young adult human (21-34)
项目摘要
The specific aims of this project are to: (1) Dissociate immediate and delayed effects of acutely elevated cortisol levels on cognitive function; and (2) Establish the relationship between the magnitude of acute increases in cortisol secretion and changes in long-term memory. Cortisol is a steroid hormone released from the adrenal glands in response to physical or psychological stress. A number of studies have reported cognitive changes in humans associated with acute and chronic elevations in cortisol, including deficits in attention and verbal memory. It is reasonable to presume that these cognitive changes are the result of cortisol's actions on neural tissue. We know that cortisol's effects on neural tissue are complex and nonlinear, depending on amount and timing. What we do not yet understand is how cortisol's complex interactions with neural tissue affect cognitive function. This experiment tests the proposal that stress-induced increases in cortisol will have differing effects on cognition depending on two interacting factors: (a) the duration of increase in cortisol secretion, and (b) the magnitude of increase in cortisol secretion. The immediate effects of increased cortisol may be to enhance immediate and short-term cognitive processes, (e.g. attention and memory encoding), while the delayed effects may be to interfere with long-term processes (e.g. memory consolidation and storage). At the same time, however, moderate increases in cortisol may enhance long-term processes, while relatively large increases may have detrimental effects. This experiment is designed to dissociate the duration and magnitude effects of cortisol on attention and memory. It tests three specific hypotheses: (a) Immediate attentional processes and short-term memory will be enhanced when acute elevations in cortisol are induced in the laboratory; (b) Moderate acute increases in cortisol will be associated with long-term memory enhancements ; and (c) Relatively large acute elevations in cortisol will be associated with long-term memory impairments. The hypotheses will be tested by inducing stress in a group of human participants and measuring (a) self-report, physiological, and cortisol indicators of stress, and (b) performance on attention and memory tasks. These pilot studies will provide the foundation for exploring chronic, hippocampus-mediated memory disorders associated with chronic stress and elevated cortisol.
该项目的具体目标是:(1)分离皮质醇水平急性升高对认知功能的即时和延迟影响;(2)建立皮质醇分泌急性增加的幅度与长期记忆变化之间的关系。 皮质醇是一种类固醇激素,在身体或心理压力下从肾上腺释放出来。 许多研究报告了与皮质醇急性和慢性升高相关的人类认知变化,包括注意力和言语记忆的缺陷。 我们有理由推测,这些认知变化是皮质醇作用于神经组织的结果。我们知道,皮质醇对神经组织的影响是复杂和非线性的,取决于数量和时间。 我们还不知道皮质醇与神经组织的复杂相互作用如何影响认知功能。 这个实验验证了这样一个假设,即压力诱导的皮质醇增加会对认知产生不同的影响,这取决于两个相互作用的因素:(a)皮质醇分泌增加的持续时间,(B)皮质醇分泌增加的幅度。 皮质醇增加的直接影响可能是增强即时和短期认知过程(例如注意力和记忆编码),而延迟影响可能是干扰长期过程(例如记忆巩固和存储)。然而,与此同时,皮质醇的适度增加可能会增强长期过程,而相对较大的增加可能会产生不利影响。 本实验旨在分离皮质醇对注意和记忆的持续时间和幅度效应。 它检验了三个具体的假设:(a)在实验室中诱导皮质醇急性升高时,立即注意力过程和短期记忆将得到增强;(B)皮质醇中度急性升高将与长期记忆增强有关;(c)皮质醇相对较大的急性升高将与长期记忆障碍有关。 将通过在一组人类参与者中诱导压力并测量(a)自我报告,生理和皮质醇压力指标以及(B)注意力和记忆任务的表现来测试假设。 这些试点研究将为探索与慢性压力和皮质醇升高相关的慢性、校园介导的记忆障碍提供基础。
项目成果
期刊论文数量(0)
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PEGGY J JENNINGS其他文献
PEGGY J JENNINGS的其他文献
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{{ truncateString('PEGGY J JENNINGS', 18)}}的其他基金
COGNITION AND THE BASAL GANGLIA IN AGING AND DISEASE
衰老和疾病中的认知和基底神经节
- 批准号:
2049093 - 财政年份:1994
- 资助金额:
$ 3.53万 - 项目类别:
COGNITION AND THE BASAL GANGLIA IN AGING AND DISEASE
衰老和疾病中的认知和基底神经节
- 批准号:
2049092 - 财政年份:1993
- 资助金额:
$ 3.53万 - 项目类别:
COGNITION AND THE BASAL GANGLIA IN AGING AND DISEASE
衰老和疾病中的认知和基底神经节
- 批准号:
3028837 - 财政年份:1992
- 资助金额:
$ 3.53万 - 项目类别: