BREAST MICROCALCIFICATION VISUALIZATION WITH ULTRASOUND

超声乳腺微钙化可视化

• 批准号: 6172727
• 负责人: Gregg E. Trahey
• 金额: $ 14.36万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-06-01 至 2001-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6172727
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; breast neoplasm /cancer diagnosis; calcification; clinical research; diagnosis design /evaluation; diagnosis quality /standard; female; human subject; image enhancement; mathematical model; ultrasonography

DESCRIPTION (Adapted from Applicant's Abstract): Microcalcifications are important diagnostic indicators in the mammographic screening of the breast. Currently, conventional x-ray mammography is the gold standard for the detection and diagnosis of microcalcifications. However, the efficacy of conventional mammography can be significantly reduced in the presence of dense breast parenchyma, which is found in approximately one in four women. Breast ultrasound is a powerful adjunct to mammography, but its role in the breast clinic is fundamentally limited by the inability of current ultrasound technology to reliably visualize microcalcifications. The improved visualization of microcalcifications with ultrasound would have a significant impact on the management of breast cancer by contributing diagnostic information in mammographically challenging cases and potentially reducing the number of unnecessary biopsies. Despite the rapid development of the state of the art of medical ultrasound, the optimization of ultrasound system design with regard to microcalcification visualization has not been investigated. The long term objective of the proposed research is to improve the visualization of microcalcifications in the breast with medical ultrasound. Using techniques that they have developed and implemented, the applicants proposed to conduct in excised tissue and in vivo studies to collect high quality ultrasound data from microcalcifications and breast tissue. These data will be used to characterize the backscatter properties of microcalcifications and breast tissue, to test the validity of the modeling of microcalcifications with the classical Faran model, to measure phase aberration in the breast, and to assess the relative impact of several physical factors on the visualization of microcalcifications. These factors will be speckle noise, spatial resolution, and phase aberration. Empirical and model results will be used to evaluate the relative efficacy of several proposed means to improve visualization, and to specify the ultrasound system performance criterion required to achieve reliable visualization. In vitro studies will also be undertaken to assess the potential of harmonic imaging techniques to improve microcalcification visualization. It is hypothesized that the optimization of system design parameters will improve the visualization of microcalcifications with ultrasound.

描述(摘自申请者摘要)：微钙化 乳房X光检查中的重要诊断指标。 目前，传统的x射线乳房X光检查是诊断乳腺癌的黄金标准。 微钙化的检测和诊断。然而，这种药物的功效 传统的乳房X光检查可以显著减少在存在 致密的乳房实质，约1/4的女性会出现这种情况。 乳房超声是乳房X光检查的强大辅助工具，但它在乳房X光检查中的作用 乳房临床从根本上受限于目前的能力 超声波技术可以可靠地显示微钙化。这个 改进的超声对微钙化的可视化将具有 对乳腺癌的管理产生重大影响 在具有挑战性的乳房X光检查病例中的诊断信息 减少不必要的活组织检查的数量。尽管发展迅速， 在医学超声技术的最新发展中， 关于微钙化可视化的超声系统设计具有 没有被调查过。拟议研究的长期目标是 要改善乳房微钙化的可视化，请使用 医学超声波。使用他们开发的技术和 实施后，申请人建议在切除的组织和在 活体研究收集高质量的超声数据 微钙化和乳房组织。这些数据将用于 表征微钙化和乳房的背向散射特性 组织，以测试微钙化模型的有效性 经典的Faran模型，用于测量乳房中的位相像差，并 评估几个物理因素对可视化的相对影响 微钙化。这些因素将是散斑噪声、空间 分辨率和位相像差。将使用经验结果和模型结果 评估提出的几种改进方法的相对有效性 可视化，并指定超声系统的性能标准 实现可靠的可视化所需的。体外研究也将是 评估谐波成像技术的潜力，以改进 微钙化可视化。据推测，优化 将提高系统设计参数的可视化程度。 超声波下的微钙化。