BIOLOGY OF HHV8/KSHV G PROTEIN COUPLED RECEPTOR
BIOLOGY OF HHV8/KSHV G PROTEIN COUPLED RECEPTOR
批准号:
6164248
负责人:
MARVIN C GERSHENGORN
金额:
$33.49万
依托单位国家:
美国
项目类别:
财政年份:
1998
资助国家:
美国
项目状态:
已结题
起止时间:
1998-04-01 至 2003-02-28
中文摘要
描述:本项目主要研究HHV-8的G蛋白偶联受体
英文摘要
DESCRIPTION: This project focuses on a G protein-coupled receptor of HHV-8
which was found to be associated with Kaposi's sarcoma. It has recently
been shown that this receptor functions via the phosphoinositide-inositol
1,4,5-triphosphate-calcium-protein kinase C signal transduction pathway, to
induce cell proliferation and transformation; suggesting that HHV-8/GPCR may
play a necessary, if not sufficient role in the abnormal proliferation
exhibited by KS cells or lymphomatous B cells. The objectives of this
research are to understand the biology of HHV-8 GPCR, and its role in the
pathogenesis of KS. Three specific aims are proposed. The first is to
delineate the signaling mechanisms and modes of potential regulation of
HHV-8 GPCR, and the biological consequences of HHV-8 GPCR expression in
various cell types, such as cos, 293T, NIH 3T3, epithelial and B cells. The
second is to discover high affinity, specific ligands for HHV-8 GPCR based
on analogy to known chemokines. The third is to determine the roles of
HHV-8 GPCR in disease pathogenesis.
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BIOLOGY OF HHV8/KSHV G PROTEIN COUPLED RECEPTOR
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批准号:2653230
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项目类别:
-
资助金额:$29.47万
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财政年份:1998
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负责人:MARVIN C GERSHENGORN
-
依托单位:
BIOLOGY OF HHV8/KSHV G PROTEIN COUPLED RECEPTOR
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批准号:2882491
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项目类别:
-
资助金额:$30.16万
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财政年份:1998
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负责人:MARVIN C GERSHENGORN
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依托单位:
DYNORPHIN AND BETA CELL SENSITIZATION
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批准号:2794817
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项目类别:
-
资助金额:$16.93万
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财政年份:1998
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负责人:MARVIN C GERSHENGORN
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依托单位:
DYNORPHIN AND BETA CELL SENSITIZATION
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批准号:2906354
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项目类别:
-
资助金额:$17.29万
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财政年份:1998
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负责人:MARVIN C GERSHENGORN
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依托单位:
THYROTROPIN RELEASING HORMONE RECEPTOR MOLECULAR BIOLOGY
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批准号:2824954
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项目类别:
-
资助金额:$1.44万
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财政年份:1998
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负责人:MARVIN C GERSHENGORN
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依托单位:
DESENSITIZATION OF CALCIOTROPIC HORMONE RECEPTORS
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批准号:2145925
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项目类别:
-
资助金额:$20.68万
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财政年份:1993
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负责人:MARVIN C GERSHENGORN
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依托单位:
DESENSITIZATION OF CALCIOTROPIC HORMONE RECEPTORS
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批准号:2145923
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项目类别:
-
资助金额:$20.02万
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财政年份:1993
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负责人:MARVIN C GERSHENGORN
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依托单位:
DESENSITIZATION OF CALCIOTROPIC HORMONE RECEPTORS
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批准号:3248057
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项目类别:
-
资助金额:$18.38万
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财政年份:1993
-
负责人:MARVIN C GERSHENGORN
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依托单位:
DESENSITIZATION OF CALCIOTROPIC HORMONE RECEPTORS
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批准号:2145924
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项目类别:
-
资助金额:$19.54万
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财政年份:1993
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负责人:MARVIN C GERSHENGORN
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依托单位:
THYROTROPIN-RELEASING HORMONE RECEPTOR MOLECULAR BIOLOGY
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批准号:3244300
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项目类别:
-
资助金额:$2.58万
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财政年份:1992
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负责人:MARVIN C GERSHENGORN
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依托单位:
THYROTROPIN RELEASING HORMONE RECEPTOR MOLECULAR BIOLOGY
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批准号:2016385
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项目类别:
-
资助金额:$48.97万
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财政年份:1990
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负责人:MARVIN C GERSHENGORN
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依托单位:
THYROTROPIN-RELEASING HORMONE RECEPTOR MOLECULAR BIOLOGY
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批准号:3244299
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项目类别:
-
资助金额:$29.54万
-
财政年份:1990
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负责人:MARVIN C GERSHENGORN
-
依托单位:
THYROTROPIN-RELEASING HORMONE RECEPTOR MOLECULAR BIOLOGY
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批准号:3244302
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项目类别:
-
资助金额:$28.74万
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财政年份:1990
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负责人:MARVIN C GERSHENGORN
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依托单位:
THYROTROPIN-RELEASING HORMONE RECEPTOR MOLECULAR BIOLOGY
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批准号:2142710
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项目类别:
-
资助金额:$44.59万
-
财政年份:1990
-
负责人:MARVIN C GERSHENGORN
-
依托单位:
THYROTROPIN-RELEASING HORMONE RECEPTOR MOLECULAR BIOLOGY
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批准号:3244303
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项目类别:
-
资助金额:$41.06万
-
财政年份:1990
-
负责人:MARVIN C GERSHENGORN
-
依托单位:
THYROTROPIN RELEASING HORMONE RECEPTOR MOLECULAR BIOLOGY
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批准号:2142712
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项目类别:
-
资助金额:$7.17万
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财政年份:1990
-
负责人:MARVIN C GERSHENGORN
-
依托单位:
THYROTROPIN RELEASING HORMONE RECEPTOR MOLECULAR
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批准号:2357181
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项目类别:
-
资助金额:$8.65万
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财政年份:1990
-
负责人:MARVIN C GERSHENGORN
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依托单位:
THYROTROPIN RELEASING HORMONE RECEPTOR MOLECULAR BIOLOGY
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批准号:2656062
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项目类别:
-
资助金额:$8.65万
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财政年份:1990
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负责人:MARVIN C GERSHENGORN
-
依托单位:
THYROTROPIN-RELEASING HORMONE RECEPTOR MOLECULAR BIOLOGY
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批准号:3244304
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项目类别:
-
资助金额:$41.47万
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财政年份:1990
-
负责人:MARVIN C GERSHENGORN
-
依托单位:
THYROTROPIN RELEASING HORMONE RECEPTOR MOLECULAR BIOLOGY
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批准号:2734105
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项目类别:
-
资助金额:$52.15万
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财政年份:1990
-
负责人:MARVIN C GERSHENGORN
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依托单位:
海外基金