CENTRAL NERVOUS SYSTEM AND MUSCLE FATIGUE

中枢神经系统和肌肉疲劳

• 批准号: 6126321
• 负责人: GUANG H YUE
• 金额: $ 15.38万
• 依托单位: CLEVELAND CLINIC FOUNDATION
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-03 至 2001-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6126321
• 关键词: brain electrical activity; clinical research; direct cortical response; electroencephalography; electromyography; fatigue; functional magnetic resonance imaging; human subject; motor cortex; muscle contraction; muscle strength; neuromuscular function; neuromuscular system; psychomotor function; sensory feedback

DESCRIPTION (Adapted from the Applicant's Abstract): Muscle fatigue has been studied for over a century. Despite considerable gains in knowledge of the peripheral mechanisms underlying fatigue, very little is known about how the brain, the control center of any neuromuscular operation, modulates the activity of the fatiguing muscle. Because the functional outcome of muscle fatigue is a decline in the ability to generate force, the brain must adjust its output to maintain the desired muscle force. When a constant submaximal load or force is sustained, the surface electromyographic signal (EMG) typically increases. It is possible, therefore, that the brain also increases its activity during a low-force fatigue process. This possibility has not been tested. When a maximal force is sustained the force and EMG decline in parallel. Whether the level of brain activation changes during a sustained maximal voluntary contraction (MVC) is unknown. It is also not clear how the sensory information from the fatiguing muscle influences activities of cortical motor areas. Aim 1 is to quantify the changes in brain activation during fatigue involving MVC. Aim 2 is to determine the effect of low-force fatigue on the adjustment of brain activity. Aim 3 is to determine the effects of sensory feedback from the fatiguing muscles on brain activity. Brain activation will be determined by functional magnetic resonance imaging (fMRI) and motor-activity related cortical potential (MRCP) derived from electroencephalographic recordings (EEG). Preliminary fMRI results showed that (1) despite the differences at the periphery between the low-force (constant force, increasing EMG) and high-force (decreasing force and EMG) fatigue, the change in brain activity was surprisingly similar: brain activity increased during both tasks; (2) many higher-order cortical fields increased in activation during the later stage of the fatigue tasks; and (3) the motor cortex contralateral to the fatiguing muscle "fatigued" and the ipsilateral motor cortex increased its activity substantially as fatigue set in. It is hypothesized that (1) during both fatigue tasks (MVC and low-force), the overall brain activation level will increase, but the changes among different cortical fields will vary; (2) the higher-order motor areas and motor cortex ipsilateral to the fatiguing muscles will increase in activation during the later stage of the tasks; and (3) after blocking the sensory information from the fatiguing muscle, the contralateral motor cortex activity will increase more than when the sensory information is not blocked. Surface EMG and force will be recorded simultaneously with the brain images and MRCP data while subjects perform the fatigue tasks. This will enable the Principal Investigator to examine the central (brain) and peripheral (muscle) systems concurrently. The intent is that knowledge gained from these studies will provide primary data concerning the central nervous system activation during muscle fatigue. This knowledge will contribute to our understanding of the neuromuscular mechanisms underlying muscle fatigue and will have relevance for neurology and rehabilitation medicine.

描述（改编自申请人摘要）：

项目成果

Nonlinear features of surface EEG showing systematic brain signal adaptations with muscle force and fatigue.

• DOI: 10.1016/j.brainres.2009.03.042
• 发表时间: 2009-05-26
• 期刊: Brain research
• 影响因子: 2.9
• 作者: Yao B;Liu JZ;Brown RW;Sahgal V;Yue GH
• 通讯作者: Yue GH

Strengthened functional connectivity in the brain during muscle fatigue.

• DOI: 10.1016/j.neuroimage.2011.12.013
• 发表时间: 2012-03
• 期刊: NEUROIMAGE
• 影响因子: 5.7
• 作者: Jiang, Zhiguo;Wang, Xiao-Feng;Kisiel-Sajewicz, Katarzyna;Yan, Jin H.;Yue, Guang H.
• 通讯作者: Yue, Guang H.

Weakening of functional corticomuscular coupling during muscle fatigue.

• DOI: 10.1016/j.brainres.2008.10.074
• 发表时间: 2009-01-23
• 期刊: Brain research
• 影响因子: 2.9
• 作者: Yang Q;Fang Y;Sun CK;Siemionow V;Ranganathan VK;Khoshknabi D;Davis MP;Walsh D;Sahgal V;Yue GH
• 通讯作者: Yue GH

Shifting of activation center in the brain during muscle fatigue: An explanation of minimal central fatigue?

• DOI: 10.1016/j.neuroimage.2006.09.050
• 发表时间: 2007-03-01
• 期刊: NEUROIMAGE
• 影响因子: 5.7
• 作者: Liu, Jing Z.;Lewandowski, Beth;Yue, Guang H.
• 通讯作者: Yue, Guang H.