Neurophysiological Evaluation of Training Effect on Cancer-Related Weakness

训练对癌症相关虚弱效果的神经生理学评估

• 批准号: 9342695
• 负责人: GUANG H YUE
• 金额: $ 46.64万
• 依托单位: KESSLER FOUNDATION, INC.
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-19 至 2020-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9342695
• 关键词: Adopted; Area; Base of the Brain; Brain; Brain imaging; Breast Cancer Patient; Breast Cancer survivor; Cancer Patient; Cancer Survivor; Clinical; Control Groups; Coupling; Data; Elderly; Electroencephalography; Evaluation; Exercise; Face; Frail Elderly; Functional Magnetic Resonance Imaging; Future; Goals; Hand Strength; Imagery; Individual; Laboratories; Malignant Neoplasms; Maps; Measurement; Methods; Moderate Exercise; Motor; Motor Cortex; Movement; Muscle; Muscle Contraction; Muscle Weakness; Neuronal Plasticity; Patients; Physical Exercise; Physical Fitness; Physiological; Population; Psyche structure; Quality of life; Recruitment Activity; Rehabilitation therapy; Reporting; Research; Research Design; Safety; Signal Transduction; Skeletal Muscle; Sports; Technology; Testing; Time; Training; Training Programs; base; exercise intensity; fitness; improved; motor control; motor function improvement; motor skill learning; muscle strength; neuroadaptation; neuromuscular function; neurophysiology; patient population; programs; public health relevance; relating to nervous system; strength training; translational study; young adult

DESCRIPTION (provided by applicant): Weakness limits mobility and diminishes quality of life in many cancer survivors, especially in those who suffer from late stage of cancer. Early research suggests that high-intensity strength training (HIST) is essential to gain muscle strength. Although participating in HIST posts little difficulties for younger and healthy individuals, such training is intimidating and unsafe for many weak cancer survivors with limited physical abilities. Evidence in recent years, however, has shown that training with high effort (intended muscle contraction) combined with no or little physical exercise can significantly strengthen muscle by increasing brain-to-muscle command, which helps improve motor unit recruitment and activation level. Although the effect of high-effort training on muscle strengthening has been recognized in healthy young and older adults, nothing is known regarding its application to improving strength in weak patients, individuals who may benefit most from participating in this type of training, given difficulties they may face when engaging in conventional HIST. Further, detailed neurophysiological mechanisms behind the phenomenon of high mental effort training- induced strength gain are yet to be determined. Preliminary data from the PI's laboratory show that cancer patients with weakness undergone high-effort motor imagery training can significantly improve their strength. EEG-based movement-related cortical potential measurement demonstrates enhanced descending command to target muscle following such training. These observations led to our fundamental hypothesis that training-induced strength gain resulting from neural adaptations is not dependent on intensity of muscle exercise; rather, it relies primarily on the level of voluntary effort during training regardless o physical exercise intensity. The major goal of this study is to test this hypothesis by training weak cancer survivors with high effort plus moderate intensity (HEMI) and low effort combined with moderate intensity (LEMI) muscle exercises and evaluate strength improvement and underlying neural plasticity after training. The Aims of the study are to determine the effects of HEMI and LEMI training on handgrip strength and level of fMRI-based brain connectivity that modulates the descending command and functional brain-muscle coupling (fBMC) for maximal muscle force. It is hypothesized that the HEMI training will significantly gain strength and elevat the level of cortical network connectivity and fBMC but the LEMI will not. The findings will show that HEMI training is an effective approach to provoke neural plasticity that promotes muscle strength in breast cancer survivors with weakness. Although the results will be acquired from breast cancer patients, the method (HEMI training) is not limited to this patient population for voluntary muscle strengthening.

描述（由申请人提供）：虚弱限制了许多癌症幸存者的行动能力，并降低了生活质量，特别是那些患有晚期癌症的人。早期的研究表明，高强度力量训练（HIST）对获得肌肉力量至关重要。虽然参加HIST对年轻和健康的个人来说没有什么困难，但这种培训对许多身体能力有限的虚弱癌症幸存者来说是令人生畏和不安全的。然而，近年来的证据表明，高强度的训练（预期的肌肉收缩）结合不进行或很少的体育锻炼可以通过增加脑对肌肉的指挥来显着增强肌肉，这有助于提高运动单元的招募和激活水平。尽管高强度训练对肌肉增强的影响已经在健康的年轻人和老年人中得到了认可，但对于它在提高身体虚弱的病人力量方面的应用还不得而知，这些人可能从参加这种类型的训练中获益最多，因为他们在参与时可能面临困难