FEASIBILITY OF BIOLOGICAL MEASUREMENT IN DRUG SURVEYS

药物调查中生物测量的可行性

• 批准号: 6355469
• 负责人: MICHAEL FENDRICH
• 金额: $ 11.72万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-04-01 至 2003-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6355469
• 关键词: clinical chemistry; clinical research; data collection methodology /evaluation; drug abuse; drug detection; human subject; interview; measurement; population survey; statistics /biometry

DESCRIPTION (Adapted from the Applicant's Abstract): This work will facilitate more effective drug abuse prevention and treatment efforts on a societal level by enhancing the accuracy of drug abuse measurement. Specifically, this study will provide definitive answers regarding the viability of incorporating biological measurement of drug use in the context of general population household surveys on drug abuse. The proposed study will evaluate the feasibility and utility of three different types of biological measurement procedures (hair, saliva, and urine testing) to be used as an adjunct to a household survey on drug abuse. This study will compare the relative acceptability of the different biological test methods among survey participants through household surveys of 600 randomly selected subjects residing in the City of Chicago. By randomly assigning subjects to either a high or low incentive drug test condition, this study will evaluate the role of alternative incentive strategies on participation in biological measurement. Through quantitative and qualitative analyses, this study will assess the myriad of subject, interview condition, and procedural variables associated with drug test participation in household surveys. This study will examine impact of prior exposure to drug testing and perceptions about drug testing accuracy on willingness to participate in biological measurement. The study will also gain an understanding of adult willingness to provide consent for similar drug testing in children. Alternative statistical procedures for constructing prevalence estimators from multiple biological measures will be explored. Results derived from biological assessments will be compared with responses to questions about drug use provided in an Audio Computer Assisted Self Interview that precedes the biological assessment. Taking into account factors influencing drug test participation, these comparisons will be used to evaluate the extent of underreporting of drug use in the general population. Subject and drug use variables associated with drug use underreporting will be fully analyzed. The utility of hair testing will be further evaluated by examining whether a new confirmation process (negative ion screening) yields increased sensitivity for detecting marijuana metabolites.

描述（根据申请人的摘要改编）：这项工作将有助于 在社会层面上更有效的预防药物滥用和治疗工作 通过提高药物滥用测量的准确性。具体来说，这项研究 将提供有关合并的可行性的确切答案 在普通人群中使用药物使用的生物学测量 家庭调查药物滥用。拟议的研究将评估 三种不同类型的生物测量的可行性和效用 程序（头发，唾液和尿液测试）被用作 家庭调查药物滥用。这项研究将比较亲戚 调查中不同生物测试方法的可接受性 通过家庭调查600名随机选择的受试者的参与者 居住在芝加哥市。通过随机将受试者分配给 高或低激励药物测试条件，本研究将评估 参与生物测量的替代激励策略。 通过定量和定性分析，本研究将评估 无数主题，访谈条件和程序变量相关 随着药物测试参与家庭调查。这项研究将检查 事先接触药物测试和对药物测试的看法的影响 愿意参加生物测量的准确性。研究 还将了解成人愿意提供同意的意愿 儿童类似的药物测试。替代统计程序 通过多种生物学措施构建患病率估计值将是 探索。将生物评估得出的结果与 对音频计算机中提供的有关药物使用的问题的回答 在生物评估之前进行的自我访谈。考虑到 影响药物测试参与的因素，这些比较将用于 评估普通人群中药物使用不足的程度。 与使用毒品相关的主题和药物使用变量将是 完全分析。头发测试的效用将通过 检查新的确认过程（负离子筛选）是否产生 提高了检测大麻代谢产物的敏感性。