FEASIBILITY OF BIOLOGICAL MEASUREMENT IN DRUG SURVEYS

描述（改编自申请人的摘要）：这项工作将有助于 在社会一级作出更有效的药物滥用预防和治疗努力 提高药物滥用计量的准确性。具体来说，这项研究 将提供关于合并的可行性的明确答案 一般人群中药物使用的生物计量 关于药物滥用的住户调查。拟议的研究将评估 三种不同类型生物测量的可行性和实用性 程序（毛发、唾液和尿液测试）用作辅助治疗 关于药物滥用的家庭调查。这项研究将比较相对 调查中不同生物学试验方法的可接受性 通过对600名随机选择的受试者进行家庭调查， 居住在芝加哥市。通过将受试者随机分配到 高或低激励药物试验条件下，本研究将评估的作用， 参与生物测量的替代激励策略。 通过定量和定性分析，本研究将评估 无数的主题，采访条件和相关的程序变量 家庭调查中的药物测试参与情况。本研究将探讨 先前暴露于药物测试的影响和对药物测试的看法 参与生物测量意愿的准确性。研究 还将了解成年人愿意提供同意， 在儿童中进行类似的药物测试。替代统计程序 从多个生物学指标构建流行率估计值将是 探讨了生物学评估的结果将与 回答有关药物使用的问题提供了一个音频计算机辅助 生物学评估之前的自我面试。考虑 影响药物试验参与的因素，这些比较将用于 评价一般人群中药物使用情况报告不足的程度。 与药物使用漏报相关的受试者和药物使用变量将 全面分析。毛发检测的效用将进一步评估， 检查新的确认过程（负离子筛选）是否产生 提高检测大麻代谢物的灵敏度。

DESCRIPTION (Adapted from the Applicant's Abstract): This work will facilitate more effective drug abuse prevention and treatment efforts on a societal level by enhancing the accuracy of drug abuse measurement. Specifically, this study will provide definitive answers regarding the viability of incorporating biological measurement of drug use in the context of general population household surveys on drug abuse. The proposed study will evaluate the feasibility and utility of three different types of biological measurement procedures (hair, saliva, and urine testing) to be used as an adjunct to a household survey on drug abuse. This study will compare the relative acceptability of the different biological test methods among survey participants through household surveys of 600 randomly selected subjects residing in the City of Chicago. By randomly assigning subjects to either a high or low incentive drug test condition, this study will evaluate the role of alternative incentive strategies on participation in biological measurement. Through quantitative and qualitative analyses, this study will assess the myriad of subject, interview condition, and procedural variables associated with drug test participation in household surveys. This study will examine impact of prior exposure to drug testing and perceptions about drug testing accuracy on willingness to participate in biological measurement. The study will also gain an understanding of adult willingness to provide consent for similar drug testing in children. Alternative statistical procedures for constructing prevalence estimators from multiple biological measures will be explored. Results derived from biological assessments will be compared with responses to questions about drug use provided in an Audio Computer Assisted Self Interview that precedes the biological assessment. Taking into account factors influencing drug test participation, these comparisons will be used to evaluate the extent of underreporting of drug use in the general population. Subject and drug use variables associated with drug use underreporting will be fully analyzed. The utility of hair testing will be further evaluated by examining whether a new confirmation process (negative ion screening) yields increased sensitivity for detecting marijuana metabolites.