Developmental aspects of respiratory inflammation, allergy and asthma

呼吸道炎症、过敏和哮喘的发育方面

• 批准号: nhmrc : 458513
• 负责人: Prof John Upham
• 金额: $ 478.07万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: Programs
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/developmental-aspects-respiratory-allergy-asthma/101211
• 关键词: Developmental; aspects; respiratory; inflammation; allergy

Asthma develops as a complex series of interactions between genetic susceptibility and environmental exposures occurring in early life. While many children grow out of asthma others do not and develop the chronic form of the disease that persists into adult life. Our research involves understanding why some susceptible children develop asthma and why this becomes chronic in some. We will undertake studies in children to find out how and why this occurs. A major part of our studies involve longitudinal studies in cohorts of children recruited before birth. Having the ability to study children as they grow and develop conditions such as allergies and asthma allows us to understand why these conditions occur and allow us to predict which children are likely to develop them. Our research Program also has a solid focus on Translational Research, in which we will use the findings from our basic science studies to develop and test new methods of preventing and of treating asthma. These studies will include new methods for preventing the development of allergies, preventing the damage done to the lungs by severe viral respiratory infections in early life and better methods of treating established allergic asthma by improving immunotherapy techniques. By its very nature, primary prevention of disease in young children is controversial and raises some interesting questions. As part of this Program we intend to initiate consultation and debate in public, academic, regulatory and industry circles. An important role for our Program is shifting the current emphasis away from treatment of established disease towards preventing disease occurring. This is the best way to decrease the health, social and economic burden of chronic diseases such as asthma.

哮喘的发展是遗传易感性和早期生活中发生的环境暴露之间的一系列复杂的相互作用。虽然许多儿童长大后会患上哮喘，但其他儿童却不会，并会发展成慢性哮喘，并持续到成年。我们的研究涉及了解为什么一些易感儿童会患上哮喘，以及为什么在一些儿童中会变成慢性。我们将在儿童中进行研究，以找出这种情况是如何发生的以及为什么会发生。我们的研究的一个主要部分涉及在出生前招募的儿童队列的纵向研究。有能力研究儿童，因为他们的成长和发展条件，如过敏和哮喘，使我们能够了解为什么这些条件发生，并使我们能够预测哪些儿童可能发展他们。我们的研究计划也有一个坚实的重点转化研究，其中我们将使用我们的基础科学研究的结果来开发和测试预防和治疗哮喘的新方法。这些研究将包括预防过敏发展的新方法，预防早期严重病毒性呼吸道感染对肺部造成的损害，以及通过改进免疫治疗技术治疗已建立的过敏性哮喘的更好方法。就其本质而言，幼儿疾病的一级预防是有争议的，并提出了一些有趣的问题。作为该计划的一部分，我们打算在公共、学术、监管和行业界发起磋商和辩论。我们的计划的一个重要作用是将目前的重点从治疗已确定的疾病转向预防疾病的发生。这是减少哮喘等慢性疾病的健康、社会和经济负担的最佳方法。