THE WEINSTEIN CONFERENCE ON CARDIOVASCULAR DEVELOPMENT

描述(申请人的逐字描述)：部分支持是 为正在进行的年度“温斯坦会议”申请3年 心血管发展。“这一会议由 康斯坦斯·温斯坦博士，前NHLBI工作人员，致力于 了解潜在的分子和细胞生物学机制的目标 脊椎动物心血管发育。在过去的5年里，这次会议 250-300名与会者成为心血管领域的首要会议 发展，汇聚了来自主要和不同领域的代表 在这个地区工作的实验室。这次会议是在以下指导下组织的 “温斯坦会议委员会”是一个常设组织，拥有 制定了宪章，由该领域的领导人组成，并轮流到 温斯坦委员会成员在家庭机构的不同地点。 会议的具体目的是：(一)交流基本情况 关于特定基因及其相互作用机制的研究 蛋白质产物在正常人心脏和血管发育中的作用 心脏形态发生与人和动物异常发育模型 导致先天性心脏病、心肌病和心律失常。(Ii)至 促进基础实验室和临床科学家的互动 参与人类缺陷诊断和评估的专业人员 心血管发展，以鼓励合作方法 调查；及(Iii)鼓励年青侦探追求事业 涉及心血管发育。口头报告的主题包括 心脏形态，心脏功能，人类心血管缺陷的遗传学， 实验心血管胚胎学，心肌细胞结构和组织， 心血管系统中基因表达的调节，转基因和 心血管疾病的小鼠模型为空。最近发生的爆炸事件 描述正常心脏和血管发育所必需的基因和 人类和小鼠基因突变导致异常的发现 心血管发展强调这些会议的及时性。国立卫生研究院 支持将为学生和研究员提供更多的机会， 稳定这些会议的年度计划，并增加 妇女和少数群体的代表相当于会议参与者。

DESCRIPTION (the applicant's description verbatim): Partial support is requested for 3 years for the ongoing annual "Weinstein Conference on Cardiovascular Development." This meeting, established and coordinated by Constance Weinstein, Ph.D., formerly of the NHLBI staff, is dedicated to the goal of understanding the molecular and cell biological mechanisms underlying vertebrate cardiovascular development. Over the last 5 years, this meeting of 250-300 participants has become the premier conference on Cardiovascular Development and brings together representatives from the major and diverse laboratories working in this area. The meeting is organized under direction of the "Weinstein Conference Committee," a permanent organization with an established Charter and composed of leaders in this field, and rotates to different sites at the home institutions of members of the Weinstein Committee. The specific aims for the meeting are (i) to communicate results of basic investigation concerning the mechanisms by which specific genes and their protein products mediate cardiac and vascular development both in normal cardiac morphogenesis and in humans and animal models of aberrant development resulting in congenital heart disease, cardiomyopathy, and arrhythmias. (ii) to promote interactions of scientists from basic laboratories and clinical specialties involved in diagnosis and evaluation of humans with defects in cardiovascular development to encourage collaborative approaches to investigation, and (iii) to encourage young investigators to pursue careers involved cardiovascular development. Topics presented at oral session include cardiac morphology, cardiac function, genetics of human cardiovascular defects, experimental cardiovascular embryology, myocyte structure and organization, regulation of gene expression in the cardiovascular system, and transgenic and null mouse models of cardiovascular disease. The recent explosion in delineation of genes essential for normal cardiac and vascular development and discovery of mutations in human and murine genes causing aberrant cardiovascular development emphasizes the timeliness of these conferences. NIH support would provide increased accessibility for students and fellows, stabilization of year to year planning for these meetings, and increase representation of women and minorities amount conference participants.