Pediatric Center for Gene Expression and Development

描述(申请人提供)：此申请是为了继续资助我们的儿童健康研究职业发展奖(CHRCDA)，该奖项建立了一个独特的卓越中心，旨在加强儿科学的基础和临床研究培训，重点是分子和细胞生物学和临床科学。这是这笔赠款的第三次续期。我们的CHRCDA已经支持了我们机构的32名学者，其中许多人已经成为学术儿科学的国家领导者。我们的学者总共发表了644篇论文，获得了5000多万美元的资助(其中包括28篇R01《S》)。该中心加强年轻儿科教师的学术生涯发展，提供导师和核心设施，旨在根据学术生涯的需要加强儿科医生的培训。该中心被整合到创新的既定研究培训计划中，包括普罗科特学者计划和NIH资助的广泛研究计划。该计划确定并招募有前途的年轻儿科教师，他们在CHRCDA计划内完成2-3年期的研究加强计划，该计划由高级科学家导师组成，他们共同关注分子细胞生物学、分子医学或临床科学。职业发展包括：1)中心工作人员研究人员的个人指导；2)分子遗传学、发育生物学、临床研究、流行病学和翻译研究方面的正式和非正式培训；3)核心研究要素，优先培训各种研究方法，包括分子生物学、免疫学、基因组学和转基因/基因靶向模型。目前的建议汇集了儿童医院和辛辛那提大学医学院在发展科学方面具有卓越成就的资深研究人员。为了实现我们的培训目标，我们提出了一个由四个部分组成的中心：1)中心工作人员研究人员在哺乳动物发育研究、分子医学和临床研究中应用分子和细胞生物学和信息学技术方面具有共同的兴趣和专业知识，作为儿科医生-学者的主要导师。2)行政核心确定招募人员并监督儿科医生-学者的全面培训。该核心为地方和国家两级的国家招聘工作提供支持，并优先考虑少数群体的招聘。3)研究核心促进了分子和细胞生物学、临床研究/流行病学和统计学在儿科学者的研究计划中的应用。4)研究资助提供为期2-3年的儿科医生-学者研究经费和导师。这一当代分子、细胞、发育生物学和临床科学方面的个人指导和高级培训相结合的计划，提高了我们的医生-学者在儿科科学领域开始高产出学术生涯时的培训和研究效率。

DESCRIPTION (provided by applicant): This application is for continued funding for our Child Health Research Career Development Award (CHRCDA), which has established a unique center of excellence for the enhancement of basic and clinical research training in pediatrics with focus on molecular and cellular biology and clinical sciences. This is the third renewal of this grant. Our CHRCDA has supported 32 scholars at our institution, many of whom have become national leaders in academic pediatrics. Collectively, our scholars have published ~644 papers and obtained over $50 million in grant dollars of funding (including 28 R01's). The Center enhances academic career development of young pediatric faculty, providing mentorship and Core facilities designed to enhance the training of pediatricians as required for an academic career. The Center is integrated into innovative established programs for research training including the Procter Scholar Program and extensive NIH funded research programs. The program identifies and recruits promising young pediatric faculty who complete a 2- 3 year program for research enhancement within a CHRCDA program comprised of senior scientist mentors who share a central focus in molecular-cellular biology, molecular medicine or clinical sciences. Career development includes: 1) individual mentorship by Center staff investigators; 2) formal and informal training in molecular genetics, developmental biology, clinical research, epidemiology, and translational research; and 3) Core research elements which prioritizes training in diverse research approaches including molecular biology, immunology, genomics and transgenic/gene targeting models. The present proposal has drawn together established investigators with excellence in developmental science at the Children's Hospital and the University of Cincinnati College of Medicine. To meet our training goals, a four-part Center is proposed: 1) Center staff investigators who share interest and expertise in the application of molecular and cellular biology and informatics technology in the study of mammalian development, molecular medicine, and clinical research serve as primary mentors for the pediatrician-scholars. 2) Administrative Core identifies recruits and monitors the overall training of pediatrician-scholars. The Core provides support for national recruitment efforts, at local and national levels and prioritizes minority recruitment. 3) Research Cores facilitate the application of molecular and cellular biology, clinical research/epidemiology and statistics to the research programs of pediatrician-scholars. 4) Research support grants provide the pediatrician-scholar research funds and mentorship for a period of 2-3 years. This combined program of individual mentorship and advanced training in contemporary molecular, cellular, developmental biology, and clinical sciences enhances the training and research productivity of our physician-scholars as they begin highly productive academic careers in pediatric science.