Pediatric Center for Gene Expression and Development

儿科基因表达和发育中心

• 批准号: 7536075
• 负责人: ARNOLD W STRAUSS
• 金额: $ 43.2万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-02-20 至 2011-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7536075
• 关键词: Child health care; Childhood; Clinical Research; Clinical Sciences; Core Facility; Development; Developmental Biology; Elements; Epidemiology; Facility Designs; Faculty; Funding; Gene Expression; Gene Targeting; Genomics; Goals; Grant; Immunology; Individual; Informatics; Institution; K-Series Research Career Programs; Medicine; Mentors; Mentorship; Minority; Modeling; Molecular; Molecular Biology; Molecular Genetics; Molecular Medicine; Molecular and Cellular Biology; Monitor; NCI Scholars Program; Paper; Pediatric Hospitals; Pediatrics; Productivity; Publishing; Recruitment Activity; Research; Research Personnel; Research Support; Research Training; Science; Senior Scientist; Technology; Training; Transgenic Organisms; Translational Research; United States National Institutes of Health; Universities; career; career development; college; innovation; interest; meetings; pediatrician; programs; statistics

This application is for continued funding for our Child Health Research Career Development Award (CHRCDA), which has established a unique center of excellence for the enhancement of basic and clinical research training in pediatrics with focus on molecular and cellular biology and clinical sciences. This is the third renewal of this grant. Our CHRCDA has supported 32 scholars at our institution, many of whom have become national leaders in academic pediatrics. Collectively, our scholars have published ~644 papers and obtained over $50 million in grant dollars of funding (including 28 R01's). The Center enhances academic career development of young pediatric faculty, providing mentorship and Core facilities designed to enhance the training of pediatricians as required for an academic career. The Center is integrated into innovative established programs for research trainmg including the Procter Scholar Program and extensive NIH funded research programs. The program identifies and recruits promising young pediatric faculty who complete a 2- 3 year program for research enhancement within a CHRCDA program comprised of senior scientist mentors who share a central focus in molecular-cellular biology, molecular medicine or clinical sciences. Career development includes: 1) individual mentorship by Center staff investigators; 2) formal and informal training in molecular genetics, developmental biology, clinical research, epidemiology, and translational research; and 3) Core research elements which prioritizes training in diverse research approaches including molecular biology, immunology, genomics and transgenic/gene targeting models. The present proposal has drawn together established investigators with exceljence in developmental science at the Children's Hospital and the University of Cincinnati College of Medicine. To meet pur training goals, a four-part Center is proposed: 1) Center staff investigators who share interest and expertise in the application of molecular and cellular biology and informatics technology in the study of mammalian development, molecular medicine, and clinical research serve as primary mentors for the pediatrician-scholars. 2) Administrative Core identifies recruits and monitors the overall training of pediatrician-scholars. The Core provides support for national recruitment efforts, at local and national levels and prioritizes minority recruitment. 3) Research Cores facilitate the application of molecular and cellular biology, clinical research/epidemiology and statistics to the research programs of pediatrician-scholars. 4) Research support grants provide the pediatrician-scholar research funds and mentorship for a period of 2-3 years. This combined program of individual mentorship and advanced training in contemporary molecular, cellular, developmental biology, and clinical sciences enhances the training and research productivity of our physian-scholars as they begin highly productive academic careers in pediatric science.

此申请用于继续资助我们的儿童健康研究职业发展奖 （CHRCDA），它建立了一个独特的卓越中心，以加强基础和临床 儿科研究培训，重点是分子和细胞生物学以及临床科学。这是 第三次续展该补助金。我们的 CHRCDA 为我们机构的 32 名学者提供了支持，其中许多人拥有 成为全国儿科学术领导者。我们的学者总共发表了约 644 篇论文 获得超过 5000 万美元的资助资金（包括 28 R01）。中心提升学术水平 年轻儿科教师的职业发展，提供指导和核心设施，旨在提高 儿科医生学术生涯所需的培训。该中心融入创新 制定了研究培训计划，包括 Procter 学者计划和 NIH 广泛资助的计划 研究计划。该计划确定并招募有前途的年轻儿科教师，他们完成了 2- 由资深科学家导师组成的 CHRCDA 计划内的 3 年研究增强计划 他们共同关注分子细胞生物学、分子医学或临床科学。职业 发展包括： 1) 中心研究人员的个人指导； 2）正式和非正式培训 分子遗传学、发育生物学、临床研究、流行病学和转化研究； 3) 核心研究要素，优先考虑多种研究方法的培训，包括分子研究方法 生物学、免疫学、基因组学和转基因/基因靶向模型。目前的提案已经吸引了 共同组建了儿童医院发育科学领域杰出的研究人员， 辛辛那提大学医学院。为了实现 pur 培训目标，建议建立一个由四部分组成的中心： 1) 中心研究人员在分子和细胞应用方面有共同的兴趣和专业知识 哺乳动物发育、分子医学和临床研究中的生物学和信息学技术 研究是儿科医生学者的主要导师。 2) 行政核心确定新员工 并监督儿科医生学者的整体培训。核心为全国招聘提供支持 地方和国家层面的努力，并优先考虑招募少数族裔。 3）研究核心促进 分子和细胞生物学、临床研究/流行病学和统计学在研究中的应用 儿科医生学者项目。 4) 研究资助提供儿科医生学者的研究 资金和指导为期2-3年。这个结合了个人指导和 当代分子、细胞、发育生物学和临床科学的高级培训 提高我们的医生学者的培训和研究生产力，因为他们开始高产 儿科科学的学术生涯。