NNFF CONSORTIUM:MOLECULAR AND CELL BIOLOGY OF NF1& NF2

NNFF 联盟：NF1 的分子和细胞生物学

• 批准号: 6165831
• 负责人: KEVIN M. SHANNON
• 金额: $ 2.3万
• 依托单位: CHILDREN'S TUMOR FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-05-24 至 2001-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6165831
• 关键词: cell biology; meeting /conference /symposium; molecular biology; neurofibromatosis; travel

Funding is requested to support the next meeting of the National Neurofibromatosis Foundation International Consortium for the Molecular and Cell Biology of NF1 and NF2 to be held June 4-7, 2000 at the Hotel Jerome in Aspen, Colorado. Beginning with the first meeting in 1985, these conferences have served as the catalysts for many of the fundamental discoveries that have contributed major insights into these important diseases of the nervous system. These meetings provide a regular forum to bring together basic researchers, geneticists, clinicians, and others familiar with NF1 and NF2 to share their latest research findings and experiences. NNFF Consortia have been instrumental in the rapid advances in the molecular understanding of NF1 and NF2, including the cloning of the responsible genes, establishment of diagnostic tests, exploration of protein function, development of animal models, and creation of a network of patients and clinicians to facilitate clinical trials. The 2000 Consortium meeting has been organized as an open meeting that will be advertised to the general scientific community. Each of six platform sessions will be chaired by an expert in the field. These sessions will include 2 invited speakers from the NF research community with the other presentations to be selected from submitted abstracts. Participation by junior investigators will be encouraged and the organizers anticipate, on basis of previous Consortium meetings, that a substantial percentage of the speakers will be young investigators. Speakers will be instructed to limit their presentations to approximately half of the allotted time, with the remainder dedicated to open discussion among all participants. In addition, longer talks by four keynote speakers who are leaders in scientific fields or emerging technologies that are directly relevant to NF research will be incorporated into some of the scientific sessions. Two poster sessions will also be held which will allow investigators to present abstracts that are not selected for one of the oral sessions. In addition to updating investigators working on NF1 and NF2 on the latest research developments, this meeting will help to identify critical gaps in our knowledge as well as strategies and collaborations to address them. An improved understanding of the molecular basis of NF1 and NF2 will play an essential role in developing improved therapies for the complications of these disorders and has broad implications to the fields of developmental neurobiology and cancer research.

要求提供资金，以支持将于2000年6月4日至7日在科罗拉多白杨的杰罗姆酒店举行的NF1和NF2分子和细胞生物学国家神经纤维瘤病基金会国际联盟的下一次会议。从1985年的第一次会议开始，这些会议已经成为许多基本发现的催化剂，这些发现为这些重要的神经系统疾病提供了重要的见解。这些会议提供了一个定期论坛，将基础研究人员，遗传学家，临床医生和其他熟悉NF1和NF2的人聚集在一起，分享他们的最新研究成果和经验。NNFF联盟在NF1和NF2分子理解的快速发展中发挥了重要作用，包括克隆相关基因、建立诊断测试、探索蛋白质功能、开发动物模型以及创建患者和临床医生网络以促进临床试验。2000年联合会会议是一次公开会议，将向一般科学界作宣传。六场平台会议均将由该领域的专家主持。这些会议将包括2名来自NF研究社区的特邀演讲者，其他演讲将从提交的摘要中选出。将鼓励初级调查员参加会议，组织者预计，根据以往的联合会会议，发言者中将有相当大比例的年轻调查员。将指示发言者将其发言时间限制在分配时间的一半左右，其余时间用于所有与会者之间的公开讨论。此外，四位主题演讲者的长篇演讲将被纳入一些科学会议，他们是与NF研究直接相关的科学领域或新兴技术的领导者。还将举行两次海报会议，使研究者能够提交未被选入其中一次口头会议的摘要。除了更新NF1和NF2研究人员的最新研究进展外，本次会议将有助于确定我们知识中的关键差距以及解决这些问题的战略和合作。对NF1和NF2的分子基础的更好理解将在开发针对这些疾病的并发症的改进疗法中发挥重要作用，并对发育神经生物学和癌症研究领域具有广泛的影响。