BIRTH CERTIFICATE LINKAGE TO GROWTH & HEALTH MEASURES USING NHANESIII

出生证明与成长的联系

• 批准号: 6162526
• 负责人: Mary D Overpeck
• 金额: --
• 依托单位: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6162526
• 关键词: African American; Mexican Americans; automated medical record system; biomarker; blood chemistry; body physical characteristic; child (0-11); child physical development; clinical research; disease /disorder proneness /risk; ear infection; embryo /fetus drug adverse effect; epidemiology; health surveys; human data; human population study; low birth weight infant human; maternal behavior; nicotine; premature infant human; racial /ethnic difference; respiratory disorder; socioeconomics; tobacco abuse; urinalysis; vital statistics

The third National Health and Nutrition Examination Survey (NHANESIII) collected descriptive data, physical measures, and biomedical samples (blood and urine) on a representative U.S. sample of children at ages two months through six years with over sampling for Blacks and Mexican Americans. Serum cotinine levels were measured and information on prenatal maternal smoking obtained. NICHD supported acquisition of birth certificates from the States to link the extensive data from NHANESIII to the child's birth certificate to use the prenatal and birth information. Results of the linkage are being used in research efforts on the following: 1) to determine if low birth weight or premature children have subsequent poor health as measured by biomedical markers in a representative national sample of children through age six; 2) to assess the effects of ethnic/racial and socioeconomic factors on these outcomes; 3) to develop normative growth and other biomedical scales for a U.S. representative population, and Black and Mexican-American children, according to a risk profile at birth; and 4) to develop comparisons between maternal and proxy reports of children's risk factors at birth and actual measurements for use in other studies. The first findings include the following: 1) Significant effects of birth weight on growth persist through the first six years of age at p<0.001. The relative deficits for low birth weight (LBW) children and excesses for high birth weight (HBW) children are larger for linear measures (length and height) and measures of muscularity and lean body mass than measures of subcutaneous fatness. For length/height, upper arm and thigh muscle areas, LBW children were 0.5 standard deviations below the mean for normal (NBW) weight children through age six. HBW children were 0.4 standard deviations above the mean. 2) Exposure to environmental tobacco smoke (ETS) accounts for approximately 40-60% of respiratory morbidity in children ages 2 months to 5 years. ETS exposure increased the prevalence chronic bronchitis and wheezing among 2 months to 2 year olds and asthma across all ages. For household exposure, a consistent effect was seen only at 20+ cigarettes a day.

第三次全国性卫生与营养考试调查（NHANESIII） 收集的描述性数据，物理测量和生物医学样品 （血液和尿液）在美国代表性的两岁儿童样本上 几个月至六年的黑人和墨西哥人的抽样 美国人。 测量血清可替宁水平，并了解 获得产前孕产妇吸烟。 NICHD支持收购出生 来自各州的证书将NHANESIII的大量数据链接到 使用产前和出生信息的孩子的出生证明。 链接的结果正在用于研究工作中 以下：1）确定低出生体重或过早的孩子是 随后通过生物医学标记衡量的健康状况不佳 六岁的代表儿童样本； 2）评估 种族/种族和社会经济因素对这些结果的影响； 3）发展美国的规范增长和其他生物医学量表 代表人口以及黑人和墨西哥裔儿童 根据出生时的风险状况； 4）开发比较 在出生时儿童危险因素的母亲和代理报告之间 以及用于其他研究的实际测量。 第一个发现包括以下内容：1）出生的重大影响 生长量的重量持续到p <0.001的头六岁。 低出生体重（LBW）儿童的相对赤字和过度赤字 对于高出生体重（HBW），儿童的线性措施较大 （长度和身高）以及肌肉和瘦体重的度量 皮下脂肪的度量。 长度/高度，上臂和大腿 肌肉区域，LBW儿童低于平均值的0.5个标准偏差 适用于六岁的正常（NBW）体重儿童。 HBW儿童为0.4 标准偏差高于平均值。 2）暴露于环境烟草 烟雾（ET）约占呼吸发病率的40-60％ 2个月至5岁的儿童。 ETS暴露增加了患病率 2个月至2岁和哮喘的慢性支气管炎和喘息 各个年龄段。 对于家庭接触，可以看到一致的效果 每天只有20多支香烟。