BIOMARKERS FOR ORAL CANCER

口腔癌生物标志物

• 批准号: 6161821
• 负责人: D M WINN
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6161821
• 关键词: alcoholism /alcohol abuse; behavioral /social science research tag; biomarker; biopsy; cancer risk; clinical research; early diagnosis; growth factor receptors; health behavior; histopathology; human subject; interview; longitudinal human study; molecular oncology; neoplasm /cancer diagnosis; neoplastic transformation; oral mucosa; oral pharyngeal neoplasm; phenotype; preneoplastic state; tobacco abuse; tumor suppressor genes; veterans

This is a natural history study designed to identify markers of early malignant transformation that could be used in predicting which oral soft tissues are most likely to lead to oral cancer. Persons with white and or red oral mucosal lesions seen at six Department of Veterans Administration (VA) hospitals will be selected for the study. Study subjects will undergo a biopsy of all suspect oral lesions, provide information about tobacco, alcohol intake, and other habits and re- examined every four months for two years and re-biopsied as appropriate. The biopsy material will be analyzed for the presence or activity of certain molecules thought to be associated with the malignant phenotype including P53-dependent growth suppressers, viral agents, and carcinogen- metabolizing alleles. Statistical analysis will determine associations between molecular markers from the oral lesions and the lesions' histopathology and will examine how environmental, behavioral, and sociodemographic factors influence these associations. If molecules indicative of early transformation can be identified, they may be used to identify persons who should be monitored most closely for the development of oral cancer and to recognize oral cancers at the earliest, most treatable stage. During the past year the study the protocol was finalized and human subjects clearances were obtained in six VA Hospitals. Training materials were prepared and each of the site principal investigators and their assistants were trained. Fieldwork began in the sites, site visits were conducted, and questionnaire and biological materials have begun to be delivered to the Contractor and NIDR.

这是一项自然历史研究，旨在识别早期的标记物 可用于预测哪种口腔软组织的恶变 组织最有可能导致口腔癌。 白人和 或在六个退伍军人部看到红色口腔粘膜病变 将选择管理 (VA) 医院进行研究。 学习 受试者将对所有可疑的口腔病变进行活检，提供 有关烟草、酒精摄入量和其他习惯的信息，并重新 两年内每四个月检查一次，并酌情重新进行活检。 将分析活检材料的存在或活性 某些被认为与恶性表型相关的分子 包括 P53 依赖性生长抑制剂、病毒制剂和致癌物质 - 代谢等位基因。 统计分析将确定关联 口腔病变和病变的分子标记之间的关系' 组织病理学并将检查环境、行为和 社会人口因素影响这些关联。 如果分子 可以识别早期转化的指示，它们可用于 确定应该对发展进行最密切监控的人员 口腔癌的发病率以及尽早识别口腔癌 可治疗阶段。 在过去的一年里，研究方案最终确定，人类 在六家退伍军人管理局医院获得了受试者许可。 培训资料 已做好准备，每个现场主要调查员及其 助理接受了培训。 实地考察开始于现场，实地考察 并开始进行调查问卷和生物材料 交付给承包商和 NIDR。