DIFFERENCES IN FLUORIDE EXPOSURE AND EXPRESSION IN ADOLESCENTS

青少年氟化物暴露和表现的差异

• 批准号: 6161859
• 负责人: D M WINN
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6161859
• 关键词: adolescence (12-20); behavioral /social science research tag; blood chemistry; clinical research; community dental health; dental caries; dental plaque; dental survey; diet; dietary constituent; epidemiology; fluoridation; fluorine; fluorosis; health services research tag; human subject; nutrition related tag; questionnaires; saliva; urinalysis; water supply; water treatment

The objective of this study is to explain decreases in dental caries prevalence in non-fluoridated areas and to determine reasons for any increases in dental fluorosis. The study will include the collection of comprehensive data on exposure to fluoride from all sources by children and adolescents. Two communities located in a geographic region classified as a "high fluoridation" area -- one with a central water supply which is "fluoride deficient" (less than 0.3 ppm fluoride) and one which has been optimally fluoridated continuously since 1980 or earlier-- were selected for study. Within each community approximately 400 (ages 12 and 13 years) life-long residents were asked to participate in the study. These subjects were examined for dental caries and enamel fluorosis. Samples of plaque, saliva, blood and urine were collected from the subjects and evaluated for their fluoride concentrations. A dietary data and a detailed information on residence and fluoride-use history were obtained from each subject, as well as sociodemographic, and behavioral information. In addition, water samples were collected from community sites and school buildings for analysis; and frequently consumed foods, as listed in the dietary histories, will be purchased locally and analyzed for fluoride content. Fluoride distribution in body fluids and tissues will be correlated with each other and with reported intake, clinical findings of dental enamel fluorosis, and dental caries experience. These relationships will be evaluated between the communities and between groups of individuals with different fluorosis manifestations. This year the following progress was made. The most frequently consumed foods, specific product names and methods of food preparation were determined by follow-back calls to families. The 75 products from each community were purchased, prepared and analyzed in the laboratory for fluoride content. Specific fast food items and prepared products were processed together and one determination made by brand or item name. All clinical examination data, biological specimens fluoride content, questionnaire items and food fluoride were collected, edited and data files prepared for delivery to NIDR. Preliminary analysis of clinical and biological data was initiated.

这项研究的目的是解释减少龋齿 在非氟化地区的流行率，并确定任何原因 氟牙症的增加。 该研究将包括收集 儿童接触各种来源氟化物的综合数据 和青少年。 位于同一地理区域的两个社区 被列为“高氟化”地区--一个中心水 供应“缺氟”（氟化物低于0.3 ppm）和一个 自1980年或更早以来一直在进行最佳氟化-- 被选中进行研究。 每个社区大约有400人（年龄 12和13岁）的终身居民被要求参加 study. 对这些受试者进行龋齿和牙釉质检查 氟中毒 牙菌斑、唾液、血液和尿液样本收集自 并评估受试者的氟化物浓度。 膳食 数据和详细的信息，居住和氟化物的使用历史， 从每个受试者中获得，以及社会人口统计学和行为 信息. 此外，从社区采集水样， 用于分析的场所和学校建筑;以及经常食用的食物， 如饮食史中所列，将在当地购买并分析 氟化物含量。 氟在体液和组织中的分布 将相互关联，并与报告的摄入量、临床 氟斑牙的发现和龋齿的经验。 这些 将评估社区之间和群体之间的关系 不同氟中毒表现的个体。 今年取得了以下进展。 最常消费的 食品，具体产品名称和食品制备方法， 通过对家庭的后续电话来确定。 75个产品，每个 社区购买，准备和分析在实验室， 氟化物含量 具体的快餐项目和准备的产品， 一起处理，并通过品牌或项目名称进行一次确定。 所有 临床检查资料，生物标本氟含量， 收集、整理调查表项目和食物氟含量， 准备交付给NIDR的文件。 临床及病理初步分析 生物学数据已经启动。