ORAL PHYSIOLOGY OF AGING

衰老的口腔生理学

• 批准号: 2572359
• 负责人: D M WINN
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2572359
• 关键词: aging; biomarker; clinical research; dental alveolus; dental disorder diagnosis; dental research; disease /disorder proneness /risk; early diagnosis; epidemiology; human data; human subject; longitudinal human study; oral health; pathologic bone resorption

The oral research component of the Baltimore Longitudinal Study of Aging (BLSA), since its inception in 1978, has been designed and conducted by the NIDR to evaluate the physiological and pathological factors that influence the oral health and function of individuals of different ages. The BLSA is a large longitudinal study with an open- panel design conducted by the National Institute on Aging to investigate a range of scientific hypotheses about the aging process. Human volunteers return periodically to the BLSA site to undergo multiple health assessments including the oral health evaluation made by Branch staff. The Division of Epidemiology and Oral Disease Prevention has broadened the scope of the oral research component to include studies of alveolar bone loss in the oral cavity, the detection and application of oral molecular biological markers for systemic disease, and an expanded periodontal evaluation implementing protein markers and DNA microbial probes for early disease detection. The DEODP is also working with the BLSA to increase minority enrollment thereby increasing the diversity of the study's population base. The implementation of these additional areas of investigation within the BLSA presents an opportunity to enhance the overall understanding of age-related changes in the oral cavity.

巴尔的摩纵向研究的口腔研究部分， 老龄化（BLSA），自1978年成立以来，一直设计和 由NIDR进行，以评估生理和病理 影响个人口腔健康和功能的因素 不同年龄 BLSA是一项大型纵向研究，具有开放性- 由国家老龄化研究所进行的面板设计， 调查一系列关于衰老过程的科学假设。 人类志愿者定期返回BLSA站点， 多项健康评估，包括口腔健康评估 由分支工作人员执行。 流行病学和口腔疾病部 预防扩大了口腔研究的范围， 包括对口腔中牙槽骨丢失的研究， 口腔癌分子生物学标志物的检测及应用 系统性疾病，以及扩大牙周评估实施 蛋白质标记和DNA微生物探针用于早期疾病检测。 DEODP还与BLSA合作， 从而增加研究人群的多样性 基地 这些额外调查领域的实施 在BLSA内提供了一个机会，以提高整体 了解口腔中与年龄相关的变化。