ASSESSMENT OF SALIVA AS A MATRIX FOR THE BIOCHEMICAL VALIDATION OF FAT INTAKE

评估唾液作为脂肪摄入生化验证的基质

• 批准号: 6161860
• 负责人: H C GIFT
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6161860
• 关键词: clinical chemistry; clinical research; dietary lipid; female; human subject; longitudinal human study; method development; nutrient intake activity; nutrition related tag; saliva; women's health

In recent years epidemiologists and other medical researchers have become increasingly interested in the effects that diet may have on health and disease. The chief impediment to research on nutritional causes of disease has been uncertainty about the validity of existing dietary assessment methods and the consequent uncertainty about the results obtained from them. Ascertainment of fat intake by means of salivary analyses affords an attractive alternative to more conventional procedures that are either subjective or invasive. Positive outcomes along this line of investigative research will facilitate the conduct of valid and useful research on various chronic diseases, including cancer and heart disease. Data are currently being analyzed for this prospective study exploring the utility of salivary lipid profiles as an adjunct to more traditional dietary assessment methods among women enrolled in the Women's Health Trial (WHT) Feasibility Study in Minority Populations. Study volunteers were followed in the central study but in addition donated saliva at baseline, 3 month and 6 month follow-up. The collected saliva specimens were stored and shipped to the analytic laboratory at Texas A & M University for lipid analyses. As of July 1997 all lipid analyses had been completed. Data from the salivary component presently are being collated with pertinent data from the Women's Health Trial in order to evaluate the associations among salivary lipids, blood lipids, dietary intake data, and other pertinent variables.

近年来，流行病学家和其他医学研究人员已经成为 人们越来越关注饮食对健康的影响， 疾病 研究营养原因的主要障碍是 疾病一直是不确定的有效性，现有的饮食 评估方法和结果的不确定性 从他们那里获得的。 通过唾液确定脂肪摄入量 分析提供了一个有吸引力的替代更传统的程序 主观的或侵入性的。 沿着这条路线取得沿着的积极成果 调查研究将有助于进行有效和有益的 研究各种慢性疾病，包括癌症和心脏病。 目前正在分析这项前瞻性研究的数据， 唾液脂质谱作为更传统的 参加妇女健康中心的妇女的饮食评估方法 试验（WHT）在少数民族人群中的可行性研究。研究志愿者 在中心研究中进行了随访， 基线、3个月和6个月随访。 收集的唾液标本 被储存并运送到德克萨斯A & M的分析实验室 大学的脂质分析。 截至1997年7月，已完成所有血脂分析。的数据 目前正在将唾液成分与来自 妇女健康试验，以评估 唾液脂质、血脂、饮食摄入数据和其他相关数据 变量