NEUROGENESIS AND GLIOGENESIS IN THE DEVELOPING BRAIN

检测星形胶质细胞培养物支持神经元的能力， 在文化中的生存能力。 人胚胎神经元在培养中保持活力 如果与人胎儿星形胶质细胞共培养，持续8-10周。 这些 细胞产生神经生长因子（NGF）以及白细胞介素6（IL-6）， 6）。 研究它们产生其他神经营养因子的能力， 脑源性神经营养因子（BDNF）和胶质源性 神经营养因子（GDNF）的研究正在进行中。 表型特征 胎儿神经元表明，星形胶质细胞的支持有助于其 长寿和文化活动。 体内实验正在进行中 在啮齿动物和非人类灵长类动物的研究中。 我们还发现了培养物中的细胞聚集体， 表皮生长因子（EGF）。 这些细胞可以 代表了神经干细胞，它可以自我更新， 祖先。

Astrocyte cultures were examined for their ability to support neuronal viability in culture. Human fetal neurons remained viable in culture for 8-10 weeks if co-cultivated with human fetal astrocytes. These cells produced nerve growth factor (NGF) as well as interleukin 6 (IL- 6). Investigations of their ability to produce other neurotrophins such as brain-derived neurotrophic factor (BDNF) and glial-derived neurotrophic factor (GDNF) are ongoing. Phenotypic characteristics of fetal neurons suggest that support from astrocytes contributes to their longevity and activity in culture. In vivo experiments are now underway in rodent and nonhuman primate studies. We have also identified aggregates of cells in culture that are testing positive and respond to epidermal growth factor (EGF). These cells may represent neural stem cells which can self-renew as well as give rise to progenitors.