Sub-lethal Effects of Manufactured Nanoparticles on Fish: Bioenergetics, Brain, and Behaviour

人造纳米粒子对鱼类的亚致死效应：生物能量学、大脑和行为

• 批准号: NE/G001812/1
• 负责人: Richard Daniel Handy
• 金额: $ 52.85万
• 依托单位: Plymouth University
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2009
• 资助国家: 英国
• 起止时间: 2009 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=NE%2FG001812%2F1
• 关键词: Sub; lethal; Effects; Manufactured; Nanoparticles

Manufactured nanomaterials are new materials that have many potential beneficial applications (e.g., new textiles, electronics, building materials, medical devices etc.). However, like any substance, they must be assessed for their safety and effects on the environment. Our recent laboratory work has shown that some nanomaterials are toxic to fish, and one particular area of concern is neurotoxicity, effects on the brain, and on behaviour. This project aims to investigate these effects in detail by exposing rainbow trout to two different materials; carbon nanotubes and titanium dioxide nanoparticles. We will measure subtle changes in animal behaviour and correlate this with changes in the brain tissue (measured using physiological, histological and molecular techniques). The project also includes a risk assessment workshop, where we will discuss the results, and enable some decisions on how much of these new materials can be released into the environment and what the hazards are to wildlife, and human health.

人造纳米材料是具有许多潜在有益应用的新材料（例如，新纺织品、电子、建筑材料、医疗器械等）。然而，像任何物质一样，必须评估它们的安全性和对环境的影响。我们最近的实验室工作表明，一些纳米材料对鱼类有毒，一个特别值得关注的领域是神经毒性，对大脑和行为的影响。该项目旨在通过将虹鳟鱼暴露于两种不同的材料来详细研究这些影响;碳纳米管和二氧化钛纳米颗粒。我们将测量动物行为的细微变化，并将其与脑组织的变化（使用生理学，组织学和分子技术测量）相关联。该项目还包括一个风险评估研讨会，我们将讨论结果，并就这些新材料中有多少可以释放到环境中以及对野生动物和人类健康的危害做出一些决定。

项目成果

Minimal effects of waterborne exposure to single-walled carbon nanotubes on behaviour and physiology of juvenile rainbow trout (Oncorhynchus mykiss).

水中暴露于单壁碳纳米管对虹鳟幼鱼（Oncorhynchus mykiss）行为和生理的影响极小。

• DOI: 10.1016/j.aquatox.2013.11.006
• 发表时间: 2014
• 期刊: Aquatic toxicology (Amsterdam, Netherlands)
• 作者: Boyle D

Lagrangian theory for cosmic structure formation with vorticity: Newtonian and post-Friedmann approximations

带有涡量的宇宙结构形成的拉格朗日理论：牛顿和后弗里德曼近似

• DOI: 10.1103/physrevd.94.083515
• 发表时间: 2016
• 期刊: Physical Review D
• 影响因子: 5
• 作者: Rampf C

Are reproduction impairments of free spawning marine invertebrates exposed to zero-valent nano-iron associated with dissolution of nanoparticles?

暴露于零价纳米铁的自由产卵海洋无脊椎动物的繁殖障碍是否与纳米颗粒的溶解有关？

• DOI: 10.3109/17435390.2011.647927
• 发表时间: 2013
• 期刊: Nanotoxicology
• 影响因子: 5
• 作者: Kadar E