MAGNETIC RESONANCE SPECTROSCOPIC NEOPLASM IMAGING

该项目的总体目标是开发质子磁共振光谱成像(MRSI)技术及其后续应用，以帮助诊断和监测肿瘤患者的治疗。作为一种非侵入性的工具，提供独特的生化信息补充传统的成像，体内磁共振成像已被证明在癌症的研究中具有重要的作用。然而，需要重大的技术改进，特别是在可靠地获取全身肿瘤的体积MRSI数据方面，才能充分发挥这一强大成像方式的临床潜力。这项建议的重点是继续开发创新的光谱技术，以便可靠和有效地收集、量化和显示这一信息。这些技术将在幻影、正常志愿者以及脑瘤患者、鳞状细胞癌转移颈淋巴结和乳腺癌患者身上进行测试。在继续技术开发的同时，我们将进行一项有重点的、控制良好的临床研究，比较质子磁共振成像和FDGPET在区分放射性坏死和复发胶质瘤方面的能力。

The overall goal of this project is the development of proton magnetic resonance spectroscopic imaging (MRSI) techniques and their subsequent application for aiding in the diagnosis and treatment monitoring of patients with tumors. As a noninvasive tool providing unique biochemical information supplemental to conventional imaging, in vivo MRSI has been shown to have a valuable role in the study of cancer. However, significant technical improvements, particularly for the reliable acquisition of volumetric MRSI data from tumors throughout the body, are needed to fully realize the clinical potential of this powerful imaging modality. This proposal is focused on the continued technical development of innovative spectroscopic techniques for the robust and efficient collection, quantification, and display of this information. The techniques will be tested on phantoms, normal volunteers, as well as patients with brain tumors, metastatic neck nodes of squamous cell carcinomas, and breast cancer. In parallel with the continued technical development, we will conduct a focused, well-controlled clinical study comparing the abilities of proton MRSI and FDG PET for differentiating radiation necrosis from recurrent glial tumors.