Hyperpolarizer for 13C MR Metabolic Imaging of Human Subjects and Animal Models

用于人类受试者和动物模型 13C MR 代谢成像的超极化器

• 批准号: 8333704
• 负责人: Daniel M Spielman
• 金额: $ 200万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-05-01 至 2015-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8333704
• 关键词: 2,4-Dinitrophenol; Advanced Development; Animal Model; Animals; Biomedical Research; Cell Nucleus; Clinic; Communities; Development; Disease; Ensure; Funding; Goals; Grant; Health; Healthcare; Heart Diseases; Human; Image; Investments; Laboratories; Magnetic Resonance Imaging; Malignant Neoplasms; Metabolic; Methods; Mission; Molecular Medicine; National Center for Research Resources; Noise; Nuclear; Pathology; Patient Care; Play; Radiology Specialty; Research; Role; Services; Signal Transduction; Stem cells; Technology; Translations; Universities; bioimaging; cellular imaging; human subject; imaging modality; improved; insight; instrumentation; magnetic resonance spectroscopic imaging; molecular imaging; pre-clinical; programs; response

DESCRIPTION (provided by applicant): This proposal is in response to the NCRR "High End Instrumentation Grant Program S10" (RFA: PAR-11- 228) to expand our investment in improved instrumentation for the advancement of biomedical research in Stanford's interdisciplinary programs including the Richard M. Lucas Center for Imaging (Lucas Center), Center for Biomedical Imaging at Stanford (CBIS), and the Molecular Imaging Program at Stanford (MIPS). Translational biomedical research is of the utmost importance today and, with the rapid advances in molecular medicine and stem cells, imaging plays a vital role. We are requesting funds to purchase a General Electric Healthcare Spinlab" dynamic nuclear polarizer needed to extend our current 13C magnetic resonance spectroscopic imaging (MRSI) efforts. Specifically, we have built a highly successful experimental hyperpolarized 13C metabolic imaging program, but, so far, only technical research and small animal studies have been conducted due to the limitations of our pre-clinical polarizer. The proposed new polarizer will allow us to build upon this program with the additional capability of performing large animal and human studies, a critical step forward in the development of this promising technology. Providing more than a 10,000 fold increase in signal-to-noise ratio (SNR) as compared to thermally polarized 13C nuclei, hyperpolarized MRS forms an important bridge between MRI and molecular imaging, and the new polarizer will enable sophisticated metabolic imaging studies of cancer, heart disease, and other pathologies while ensuring the continued development of advanced hyperpolarized 13C MRS methods for years to come. The Spinlab polarizer will be located within the Lucas Center, which operates as a university Service Center and as an NCRR-funded National Research Resource (Center for Advanced MR Technology at Stanford), supplying state-of-the-art MR instrumentation and services to the campus and broader research community. A primary mission of the Stanford Department of Radiology is the translation of promising new imaging modalities from the laboratory setting to the clinic. The acquisition of this new DNP polarizer is directly aligned with this goal and has great potential to provide new insights into health and disease, ultimately improving patient care.

描述（由申请人提供）：本提案是为了响应 NCRR“高端仪器补助计划 S10”（RFA：PAR-11-228），扩大我们对改进仪器的投资，以促进斯坦福大学跨学科项目的生物医学研究，包括理查德·M·卢卡斯成像中心（卢卡斯中心）、斯坦福大学生物医学成像中心（CBIS）和斯坦福大学分子成像项目 斯坦福大学（MIPS）。转化生物医学研究在当今至关重要，随着分子医学和干细胞的快速发展，成像发挥着至关重要的作用。我们正在请求资金购买通用电气医疗保健 Spinlab”动态核偏振器，以扩展我们当前的 13C 磁共振波谱成像 (MRSI) 工作。具体来说，我们已经建立了一个非常成功的实验性超极化 13C 代谢成像项目，但到目前为止，由于我们临床前偏振器的限制，只进行了技术研究和小动物研究。拟议的新偏振器将使我们能够在此项目的基础上进行 进行大型动物和人类研究的额外能力，这是开发这项有前途的技术的关键一步。与热极化 13C 核相比，超极化 MRS 的信噪比 (SNR) 提高了 10,000 倍以上，在 MRI 和分子成像之间架起了一座重要的桥梁，新型偏振器将能够对癌症、心脏病和其他病理学进行复杂的代谢成像研究，同时确保先进技术的持续发展。 未来几年超极化 13C MRS 方法。 Spinlab 偏振器将位于卢卡斯中心内，该中心作为大学服务中心和 NCRR 资助的国家研究资源（斯坦福大学先进 MR 技术中心）运营，为校园和更广泛的研究社区提供最先进的 MR 仪器和服务。斯坦福大学放射学系的首要任务是将有前途的新成像模式从实验室环境转化为临床应用。 诊所。此次收购 新型 DNP 偏振器与这一目标直接相关，并且具有巨大的潜力，可以提供对健康和疾病的新见解，最终改善患者护理。

项目成果

PKM2 activation sensitizes cancer cells to growth inhibition by 2-deoxy-D-glucose.

• DOI: 10.18632/oncotarget.19630
• 发表时间: 2017-10-31
• 期刊: Oncotarget
• 作者: Tee SS;Park JM;Hurd RE;Brimacombe KR;Boxer MB;Massoud TF;Rutt BK;Spielman DM
• 通讯作者: Spielman DM