MEASUREMENT OF ETHANOL METABOLISM IN RAT LIVER USING MRS OF [1-13C]PYRUVATE

使用 [1-13C]丙酮酸 MRS 测量大鼠肝脏中的乙醇代谢

• 批准号: 8169890
• 负责人: Daniel M Spielman
• 金额: $ 3.08万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8169890
• 关键词: Aerobic; Alcohol consumption; Cirrhosis; Computer Retrieval of Information on Scientific Projects Database; Ethanol Metabolism; Fatty Liver; Funding; Grant; Hepatitis; Institution; Liver; Liver diseases; Magnetic Resonance Spectroscopy; Malignant Neoplasms; Measurement; Medical; Metabolic Pathway; Metabolism; Pyruvate; Pyruvates; Rattus; Research; Research Personnel; Resources; Source; United States National Institutes of Health; Work; in vivo; liver metabolism

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. [1-13C]pyruvate is readily polarizable substrate that has been the subject of numerous magnetic resonance spectroscopy (MRS) studies of in vivo metabolism. In this work, 13C-MRS of hyperpolarized [1-13C]pyruvate is used to interrogate a metabolic pathway involved in neither aerobic nor anaerobic metabolism. In particular, ethanol consumption leads to altered liver metabolism, which when excessive is associated with adverse medical conditions including fatty liver disease, hepatitis, cirrhosis, and cancer.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 [1-13C]丙酮酸是一种容易极化的底物，已成为许多体内代谢的磁共振波谱(MRS)研究的对象。在这项工作中，超极化的[1-13C]丙酮酸的13C-MRS被用来询问既不涉及有氧代谢也不涉及无氧代谢的代谢途径。特别是，酒精摄入会导致肝脏新陈代谢改变，当过量时，会导致包括脂肪肝、肝炎、肝硬变和癌症在内的不利医疗条件。