MEASUREMENT OF ETHANOL METABOLISM IN RAT LIVER USING MRS OF [1-13C]PYRUVATE

使用 [1-13C]丙酮酸 MRS 测量大鼠肝脏中的乙醇代谢

• 批准号: 8169890
• 负责人: Daniel M Spielman
• 金额: $ 3.08万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8169890
• 关键词: Aerobic; Alcohol consumption; Cirrhosis; Computer Retrieval of Information on Scientific Projects Database; Ethanol Metabolism; Fatty Liver; Funding; Grant; Hepatitis; Institution; Liver; Liver diseases; Magnetic Resonance Spectroscopy; Malignant Neoplasms; Measurement; Medical; Metabolic Pathway; Metabolism; Pyruvate; Pyruvates; Rattus; Research; Research Personnel; Resources; Source; United States National Institutes of Health; Work; in vivo; liver metabolism

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. [1-13C]pyruvate is readily polarizable substrate that has been the subject of numerous magnetic resonance spectroscopy (MRS) studies of in vivo metabolism. In this work, 13C-MRS of hyperpolarized [1-13C]pyruvate is used to interrogate a metabolic pathway involved in neither aerobic nor anaerobic metabolism. In particular, ethanol consumption leads to altered liver metabolism, which when excessive is associated with adverse medical conditions including fatty liver disease, hepatitis, cirrhosis, and cancer.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 [1- 13 C]丙酮酸是一种易极化的底物，已成为许多体内代谢磁共振波谱（MRS）研究的主题。在这项工作中，超极化[1- 13 C]丙酮酸的13 C-MRS被用来询问既不涉及有氧代谢也不涉及无氧代谢的代谢途径。 特别是，乙醇的消耗会导致肝脏代谢的改变，当过量时会导致不良的医疗状况，包括脂肪肝、肝炎、肝硬化和癌症。