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VIRAL EVASION STRATEGIES--ANALYSIS OF THE HERPES VIRUSES HSV,VZV, AND HHV 6 & 7

VIRAL EVASION STRATEGIES--ANALYSIS OF THE HERPES VIRUSES HSV,VZV, AND HHV 6 & 7
病毒逃避策略——疱疹病毒 HSV、VZV 和 HHV 6 的分析
批准号：
6338621
负责人：
Hidde L. Ploegh
金额：
$23.64万
依托单位：
IMMUNE DISEASE INSTITUTE, INC.
依托单位国家：
美国
项目类别：
财政年份：
2000
资助国家：
美国
项目状态：
已结题
起止时间：
2000-09-01 至 2002-08-31
来源：
https://reporter.nih.gov/project-details/6338621
关键词：
Herpesviridae MHC class I antigen MHC class II antigen antigen presentation biological models gene targeting herpes simplex virus 1 herpes simplex virus 2 human herpesvirus 6 laboratory mouse microorganism immunology model design /development varicella zoster virus virus genetics virus infection mechanism

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英文摘要
The human Herpes viruses lead a life of peaceful co-existence with their host, until these viruses are reactivate from their latent state. Even though most individuals are immune to these viruses, production of new virus can nonetheless occur. Generally, this ability of the virus to do so is attributed to specific gene functions that allow the virus infected cell to become temporarily invisible to the immune system. We intend to investigate, using biochemical, cell-biological and molecular biological methods, the mechanisms by which three human Herpes viruses may do so: Varicella Zoster Virus, Human Herpesvirus-6 and human Herpesvirus-7. In addition, using the technique of gene targeting, we shall construct in animal model for HSV-1 and -2.
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