VIRAL EVASION STRATEGIES--ANALYSIS OF THE HERPES VIRUSES HSV,VZV, AND HHV 6 & 7

病毒逃避策略——疱疹病毒 HSV、VZV 和 HHV 6 的分析

• 批准号: 6338621
• 负责人: Hidde L. Ploegh
• 金额: $ 23.64万
• 依托单位: IMMUNE DISEASE INSTITUTE, INC.
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6338621
• 关键词: Herpesviridae; MHC class I antigen; MHC class II antigen; antigen presentation; biological models; gene targeting; herpes simplex virus 1; herpes simplex virus 2; human herpesvirus 6; laboratory mouse; microorganism immunology; model design /development; varicella zoster virus; virus genetics; virus infection mechanism

The human Herpes viruses lead a life of peaceful co-existence with their host, until these viruses are reactivate from their latent state. Even though most individuals are immune to these viruses, production of new virus can nonetheless occur. Generally, this ability of the virus to do so is attributed to specific gene functions that allow the virus infected cell to become temporarily invisible to the immune system. We intend to investigate, using biochemical, cell-biological and molecular biological methods, the mechanisms by which three human Herpes viruses may do so: Varicella Zoster Virus, Human Herpesvirus-6 and human Herpesvirus-7. In addition, using the technique of gene targeting, we shall construct in animal model for HSV-1 and -2.

人类疱疹病毒过着与它们的 直到这些病毒从潜伏状态被重新激活。 甚至 虽然大多数人对这些病毒具有免疫力，但新病毒的产生 病毒也可能发生。 一般来说，这种能力的病毒， 因此，这归因于特定的基因功能， 免疫系统暂时看不到细胞。 我们打算 利用生物化学、细胞生物学和分子生物学 方法，三种人类疱疹病毒可能这样做的机制： 水痘带状疱疹病毒、人疱疹病毒-6和人疱疹病毒-7。 在 此外，我们还将利用基因打靶技术， HSV-1和HSV-2的动物模型。