CORE--MUSCLE PHYSIOLOGY

肌肉生理学核心是装备齐全的体外生理学 实验室配备有经验丰富的熟练执行人员 熟练执行拟议收缩研究的人员。这 CORE将由医学博士Jon Watchko监督，并向所有人开放 首席研究员协助他们实现研究目标 评价基因治疗对骨骼肌功能的影响。在……里面 除了满足个别项目的重叠需求外，还 从而最有效地利用空间、设备和人员 人才，这一核心将加强调查人员之间的合作。这个 肌肉生理学矿石的具体目的是：1)获得自然 正常人和正常人胫前肌功能的历史数据 营养不良(营养不良蛋白缺乏的mdx)小鼠，正常和营养不良 心肌病)仓鼠，以及ii)确定阳性或阴性 病毒载体基因治疗对大鼠心脏收缩功能的影响 抗肌营养不良蛋白缺陷小鼠的胫前肌和三角肌 肌聚糖仓鼠。

The Muscle Physiology Core is a well equipped in vitro physiology laboratory staffed with experienced personnel skilled in executing personnel skilled in executing the proposed contractile studies. This Core will be supervised by Jon Watchko, M.D., and be available to all principal investigators assisting them in achieving their research goals evaluating the effects of gene therapy on skeletal muscle function. In addition to meeting the overlapping needs of individual projects and thereby being the most efficient use of space, equipment and personnel talent, this Core will enhance collaboration between investigators. The Specific Aims of the Muscle Physiology ore are to i) obtain natural history data on muscle function of the tibialis anterior in normal and dystrophic (dystrophin-deficient mdx) mice, and normal and dystrophic cardiomyopathic) hamsters, and ii) determine the positive or negative effects of viral vector gene delivery on contractile function of the tibialis anterior muscle of dystrophin deficient mice and delta- sarcoglycan hamsters.