BIOTRIBOLOGY OF DIARTHRODIAL JOINTS
关节生物摩擦学
基本信息
- 批准号:6127354
- 负责人:
- 金额:$ 21.78万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1995
- 资助国家:美国
- 起止时间:1995-06-15 至 2004-05-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION (adapted from the Investigator's abstract): This is a first renewal
application of an excellent, highly productive team of a Bioengineer (G.
Ateshian) with a Biochemist (W. Valhmu) who are studying the mechanisms of
articular cartilage lubrication and/or failure of lubrication on
loading/frictional characteristics of bovine articular cartilage. Based on
previous theories and experiments, the authors propose new experiments to
further characterize the relationships between friction and fluid
pressurization of articular cartilage. The overall theory being tested is that
pressurization shifts load away from contacting cartilage surfaces, thus
decreasing friction until pressurization subsides. Three relevant hypotheses
are to be tested in this renewal: 1/that friction depends on interstitial fluid
support load, equilibrium frictional coefficient and solid-to-solid contact;
that cartilage-on-cartilage contact fraction area is smaller than cartilage on
glass. 2/ under normal loading, cartilage always maintains high interstitial
fluid support with low friction and 3/ enzymatic degradation will defeat
interstitial load mechanisms and increase the coefficient of friction. Using a
unique load-or-displacement controlled frictional testing apparatus containing
a microchip pressure transducer to measure cartilage interstitial fluid
pressurization directly, the authors will systematically test these hypotheses
through a series of carefully thought out permutations and combinations of
load-versus-displacement controlled tests. The ability to test the fluid
pressures within cartilage samples under these various, well-controlled,
physiologically relevant loading conditions, in order to test various theories
of cartilage lubrication and friction, is extremely important and unique. The
investigators provide extensive evidence that this proposal is both logical and
feasible. Their background review on the topic, along with their papers on the
topic over the past few years are all outstanding. They provide both strong
theoretical and experimental evidence to support the concepts that they are
testing. The main concept is that fluid pressurization is critical to
controlling cartilage friction. They will test that theory using
cartilage-on-glass tests along with some very important and unique
cartilage-on-cartilage tests at stresses from 0.05Mpa-5 Mpa, frequencies of
0.0005Hz - 0.5 Hz and up to 10 percent compressive strains, with and without
enzymatic (collagenase, chondroitinase ABC and hyaluronidase) treatments.
描述(改编自研究者摘要):这是第一次更新
项目成果
期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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GERARD A. ATESHIAN其他文献
GERARD A. ATESHIAN的其他文献
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{{ truncateString('GERARD A. ATESHIAN', 18)}}的其他基金
Laser Treatment Modality for Strengthening Osteoarthritic Cartilage
强化骨关节炎软骨的激光治疗方式
- 批准号:
10321817 - 财政年份:2021
- 资助金额:
$ 21.78万 - 项目类别:
Laser Treatment Modality for Strengthening Osteoarthritic Cartilage
强化骨关节炎软骨的激光治疗方式
- 批准号:
10321592 - 财政年份:2019
- 资助金额:
$ 21.78万 - 项目类别:
Laser Treatment Modality for Strengthening Osteoarthritic Cartilage
强化骨关节炎软骨的激光治疗方式
- 批准号:
10616042 - 财政年份:2019
- 资助金额:
$ 21.78万 - 项目类别:
Multidisciplinary Engineering Training in Musculoskeletal Research
肌肉骨骼研究的多学科工程培训
- 批准号:
8324567 - 财政年份:2011
- 资助金额:
$ 21.78万 - 项目类别:
Multidisciplinary Engineering Training in Musculoskeletal Research
肌肉骨骼研究的多学科工程培训
- 批准号:
8711285 - 财政年份:2011
- 资助金额:
$ 21.78万 - 项目类别:
Multidisciplinary Engineering Training in Musculoskeletal Research
肌肉骨骼研究的多学科工程培训
- 批准号:
8520182 - 财政年份:2011
- 资助金额:
$ 21.78万 - 项目类别:
Multidisciplinary Engineering Training in Musculoskeletal Research
肌肉骨骼研究的多学科工程培训
- 批准号:
8079260 - 财政年份:2011
- 资助金额:
$ 21.78万 - 项目类别:
Optimizing Nutrient Supply in Large Engineered Cartilage Tissue Constructs
优化大型工程软骨组织结构中的营养供应
- 批准号:
8025654 - 财政年份:2010
- 资助金额:
$ 21.78万 - 项目类别:
Optimizing Nutrient Supply in Large Engineered Cartilage Tissue Constructs
优化大型工程软骨组织结构中的营养供应
- 批准号:
8312731 - 财政年份:2010
- 资助金额:
$ 21.78万 - 项目类别:
Optimizing Nutrient Supply in Large Engineered Cartilage Tissue Constructs
优化大型工程软骨组织结构中的营养供应
- 批准号:
8145587 - 财政年份:2010
- 资助金额:
$ 21.78万 - 项目类别:
相似海外基金
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- 批准号:
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- 资助金额:
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Discovery Launch Supplement
Biomechanical characterisation of joints in osteoarthritis mutant zebrafish; studying interactions between genotype and biomechanics in osteoarthritis
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- 批准号:
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- 批准号:
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- 资助金额:
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Continuing Grant
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- 资助金额:
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