BIOTRIBOLOGY OF DIARTHRODIAL JOINTS

关节生物摩擦学

基本信息

  • 批准号:
    6127354
  • 负责人:
  • 金额:
    $ 21.78万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1995
  • 资助国家:
    美国
  • 起止时间:
    1995-06-15 至 2004-05-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (adapted from the Investigator's abstract): This is a first renewal application of an excellent, highly productive team of a Bioengineer (G. Ateshian) with a Biochemist (W. Valhmu) who are studying the mechanisms of articular cartilage lubrication and/or failure of lubrication on loading/frictional characteristics of bovine articular cartilage. Based on previous theories and experiments, the authors propose new experiments to further characterize the relationships between friction and fluid pressurization of articular cartilage. The overall theory being tested is that pressurization shifts load away from contacting cartilage surfaces, thus decreasing friction until pressurization subsides. Three relevant hypotheses are to be tested in this renewal: 1/that friction depends on interstitial fluid support load, equilibrium frictional coefficient and solid-to-solid contact; that cartilage-on-cartilage contact fraction area is smaller than cartilage on glass. 2/ under normal loading, cartilage always maintains high interstitial fluid support with low friction and 3/ enzymatic degradation will defeat interstitial load mechanisms and increase the coefficient of friction. Using a unique load-or-displacement controlled frictional testing apparatus containing a microchip pressure transducer to measure cartilage interstitial fluid pressurization directly, the authors will systematically test these hypotheses through a series of carefully thought out permutations and combinations of load-versus-displacement controlled tests. The ability to test the fluid pressures within cartilage samples under these various, well-controlled, physiologically relevant loading conditions, in order to test various theories of cartilage lubrication and friction, is extremely important and unique. The investigators provide extensive evidence that this proposal is both logical and feasible. Their background review on the topic, along with their papers on the topic over the past few years are all outstanding. They provide both strong theoretical and experimental evidence to support the concepts that they are testing. The main concept is that fluid pressurization is critical to controlling cartilage friction. They will test that theory using cartilage-on-glass tests along with some very important and unique cartilage-on-cartilage tests at stresses from 0.05Mpa-5 Mpa, frequencies of 0.0005Hz - 0.5 Hz and up to 10 percent compressive strains, with and without enzymatic (collagenase, chondroitinase ABC and hyaluronidase) treatments.
描述(改编自研究者摘要):这是第一次更新

项目成果

期刊论文数量(0)
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专利数量(0)

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GERARD A. ATESHIAN其他文献

GERARD A. ATESHIAN的其他文献

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{{ truncateString('GERARD A. ATESHIAN', 18)}}的其他基金

Laser Treatment Modality for Strengthening Osteoarthritic Cartilage
强化骨关节炎软骨的激光治疗方式
  • 批准号:
    10321817
  • 财政年份:
    2021
  • 资助金额:
    $ 21.78万
  • 项目类别:
Laser Treatment Modality for Strengthening Osteoarthritic Cartilage
强化骨关节炎软骨的激光治疗方式
  • 批准号:
    10321592
  • 财政年份:
    2019
  • 资助金额:
    $ 21.78万
  • 项目类别:
Laser Treatment Modality for Strengthening Osteoarthritic Cartilage
强化骨关节炎软骨的激光治疗方式
  • 批准号:
    10616042
  • 财政年份:
    2019
  • 资助金额:
    $ 21.78万
  • 项目类别:
Multidisciplinary Engineering Training in Musculoskeletal Research
肌肉骨骼研究的多学科工程培训
  • 批准号:
    8324567
  • 财政年份:
    2011
  • 资助金额:
    $ 21.78万
  • 项目类别:
Multidisciplinary Engineering Training in Musculoskeletal Research
肌肉骨骼研究的多学科工程培训
  • 批准号:
    8711285
  • 财政年份:
    2011
  • 资助金额:
    $ 21.78万
  • 项目类别:
Multidisciplinary Engineering Training in Musculoskeletal Research
肌肉骨骼研究的多学科工程培训
  • 批准号:
    8520182
  • 财政年份:
    2011
  • 资助金额:
    $ 21.78万
  • 项目类别:
Multidisciplinary Engineering Training in Musculoskeletal Research
肌肉骨骼研究的多学科工程培训
  • 批准号:
    8079260
  • 财政年份:
    2011
  • 资助金额:
    $ 21.78万
  • 项目类别:
Optimizing Nutrient Supply in Large Engineered Cartilage Tissue Constructs
优化大型工程软骨组织结构中的营养供应
  • 批准号:
    8025654
  • 财政年份:
    2010
  • 资助金额:
    $ 21.78万
  • 项目类别:
Optimizing Nutrient Supply in Large Engineered Cartilage Tissue Constructs
优化大型工程软骨组织结构中的营养供应
  • 批准号:
    8312731
  • 财政年份:
    2010
  • 资助金额:
    $ 21.78万
  • 项目类别:
Optimizing Nutrient Supply in Large Engineered Cartilage Tissue Constructs
优化大型工程软骨组织结构中的营养供应
  • 批准号:
    8145587
  • 财政年份:
    2010
  • 资助金额:
    $ 21.78万
  • 项目类别:

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