OSTEOBLAST MEDIATED TURNOVER OF COLLAGENASE IN BONE

成骨细胞介导骨中胶原酶的周转

基本信息

项目摘要

DESCRIPTION (Adapted from the Applicant's Abstract): The principal investigator, Nicola Partridge, Ph.D., proposes to examine the mechanism of the binding, internalization and degradation of the resorptive enzyme, collagenase-3 (a.k.a., metalloproteinase 13, MMP-13) following its elaboration from the osteoblast during resorption. It is hypothesized that there is a specific receptor, the collagenase-3 receptor, which binds to collagenase-3, resulting in endocytosis that triggers a further interaction of collagenase-3 with the low-density lipoprotein receptor-related protein (LRP). The precise concentration, and hence, the biological activity of MMP-3 depends on a balance between its secretion and its receptor-mediated uptake. Based upon preliminary data that the putative receptor may be a novel lectin, the applicant proposes four Specific Aims. First, she proposes to express and examine the regulation of the collagenase-3 receptor. Secondly, she proposes to mutate the receptor to determine its functional domains that interact with collagenase-3. Thirdly, she will study the interaction of the collagenase-3 molecule with LRP. Finally, she proposes to determine the domains of the collagenase-3 molecule that bind the collagenase-3 receptor and the LRP receptor. Critical new information on the biology of this important molecule may be derived from these studies.
描述(改编自申请人的摘要): 校长 研究人员 Nicola Partridge 博士提议研究该机制 再吸收酶的结合、内化和降解, 胶原酶 3(又名金属蛋白酶 13、MMP-13)的精制后 在吸收过程中来自成骨细胞。假设有一个 特异性受体,胶原酶 3 受体,与胶原酶 3 结合, 导致内吞作用,引发胶原酶 3 进一步相互作用 与低密度脂蛋白受体相关蛋白(LRP)。精确的 浓度,因此,MMP-3 的生物活性取决于平衡 其分泌和受体介导的摄取之间的关系。根据初步 申请人提出,数据表明推定受体可能是一种新型凝集素 四个具体目标。首先,她建议表达并审查该规定 胶原酶 3 受体。其次,她建议将受体突变为 确定其与胶原酶 3 相互作用的功能域。第三,她 将研究胶原酶 3 分子与 LRP 的相互作用。最后,她 提议确定胶原酶 3 分子结合的结构域 胶原酶3受体和LRP受体。有关的重要新信息 这种重要分子的生物学可能源自这些研究。

项目成果

期刊论文数量(0)
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专利数量(0)

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Nicola C Partridge其他文献

Nicola C Partridge的其他文献

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{{ truncateString('Nicola C Partridge', 18)}}的其他基金

Skyscan 1172 Ex-vivo MicroComputed Tomography System
Skyscan 1172 离体微型计算机断层扫描系统
  • 批准号:
    8446705
  • 财政年份:
    2013
  • 资助金额:
    $ 22.84万
  • 项目类别:
NUCLEAR EVENTS IN PTH ACTION ON BONE CELLS
PTH 对骨细胞作用中的核事件
  • 批准号:
    7989030
  • 财政年份:
    2010
  • 资助金额:
    $ 22.84万
  • 项目类别:
Nuclear Events in PTH Action on Bone
PTH 对骨的作用中的核事件
  • 批准号:
    8002433
  • 财政年份:
    2010
  • 资助金额:
    $ 22.84万
  • 项目类别:
P30 Center in Craniofacial Bone Biology
P30 颅面骨生物学中心
  • 批准号:
    7934062
  • 财政年份:
    2009
  • 资助金额:
    $ 22.84万
  • 项目类别:
P30 Center in Craniofacial Bone Biology
P30 颅面骨生物学中心
  • 批准号:
    7860961
  • 财政年份:
    2009
  • 资助金额:
    $ 22.84万
  • 项目类别:
COLLAGENASE REMOVAL IN OSTEOARTHRITIS
骨关节炎中的胶原酶去除
  • 批准号:
    6375376
  • 财政年份:
    2000
  • 资助金额:
    $ 22.84万
  • 项目类别:
COLLAGENASE REMOVAL IN OSTEOARTHRITIS
骨关节炎中的胶原酶去除
  • 批准号:
    6321582
  • 财政年份:
    2000
  • 资助金额:
    $ 22.84万
  • 项目类别:
COLLAGENASE REMOVAL IN OSTEOARTHRITIS
骨关节炎中的胶原酶去除
  • 批准号:
    6534524
  • 财政年份:
    2000
  • 资助金额:
    $ 22.84万
  • 项目类别:
NUCLEAR EVENTS IN PTH ACTION ON BONE CELLS
PTH 对骨细胞作用中的核事件
  • 批准号:
    2147011
  • 财政年份:
    1996
  • 资助金额:
    $ 22.84万
  • 项目类别:
NUCLEAR EVENTS IN PTH ACTION ON BONE CELLS
PTH 对骨细胞作用中的核事件
  • 批准号:
    664058
  • 财政年份:
    1995
  • 资助金额:
    $ 22.84万
  • 项目类别:

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